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Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: cifuentes pagano e. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466
Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.
Csányi G, Cifuentes-Pagano E, Al Ghouleh I, Ranayhossaini DJ, Egaña L, Lopes LR, Jackson HM, Kelley EE, Pagano PJ. Csányi G, et al. Free Radic Biol Med. 2011 Sep 15;51(6):1116-25. doi: 10.1016/j.freeradbiomed.2011.04.025. Epub 2011 Apr 17. Free Radic Biol Med. 2011. PMID: 21586323 Free PMC article.
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.
Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ. Al Ghouleh I, et al. Free Radic Biol Med. 2011 Oct 1;51(7):1271-88. doi: 10.1016/j.freeradbiomed.2011.06.011. Epub 2011 Jun 14. Free Radic Biol Med. 2011. PMID: 21722728 Free PMC article. Review.
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