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Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.
McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K. McGillicuddy LT, et al. Among authors: cichowski k. Cancer Cell. 2009 Jul 7;16(1):44-54. doi: 10.1016/j.ccr.2009.05.009. Cancer Cell. 2009. PMID: 19573811 Free PMC article.
NF1 tumor suppressor gene function: narrowing the GAP.
Cichowski K, Jacks T. Cichowski K, et al. Cell. 2001 Feb 23;104(4):593-604. doi: 10.1016/s0092-8674(01)00245-8. Cell. 2001. PMID: 11239415 Free article. Review. No abstract available.
Comparative pathology of nerve sheath tumors in mouse models and humans.
Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M. Stemmer-Rachamimov AO, et al. Among authors: cichowski k. Cancer Res. 2004 May 15;64(10):3718-24. doi: 10.1158/0008-5472.CAN-03-4079. Cancer Res. 2004. PMID: 15150133
The NF1 tumor suppressor critically regulates TSC2 and mTOR.
Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K. Johannessen CM, et al. Among authors: cichowski k. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8573-8. doi: 10.1073/pnas.0503224102. Epub 2005 Jun 3. Proc Natl Acad Sci U S A. 2005. PMID: 15937108 Free PMC article.
A negative feedback signaling network underlies oncogene-induced senescence.
Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K. Courtois-Cox S, et al. Among authors: cichowski k. Cancer Cell. 2006 Dec;10(6):459-72. doi: 10.1016/j.ccr.2006.10.003. Cancer Cell. 2006. PMID: 17157787 Free PMC article.
TORC1 is essential for NF1-associated malignancies.
Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. Johannessen CM, et al. Among authors: cichowski k. Curr Biol. 2008 Jan 8;18(1):56-62. doi: 10.1016/j.cub.2007.11.066. Epub 2007 Dec 27. Curr Biol. 2008. PMID: 18164202 Free article.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. Min J, et al. Among authors: cichowski k. Nat Med. 2010 Mar;16(3):286-94. doi: 10.1038/nm.2100. Epub 2010 Feb 14. Nat Med. 2010. PMID: 20154697 Free PMC article.
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. De Raedt T, et al. Among authors: cichowski k. Cancer Cell. 2011 Sep 13;20(3):400-13. doi: 10.1016/j.ccr.2011.08.014. Cancer Cell. 2011. PMID: 21907929 Free PMC article.
Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.
Beert E, Brems H, Daniëls B, De Wever I, Van Calenbergh F, Schoenaers J, Debiec-Rychter M, Gevaert O, De Raedt T, Van Den Bruel A, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E. Beert E, et al. Among authors: cichowski k. Genes Chromosomes Cancer. 2011 Dec;50(12):1021-32. doi: 10.1002/gcc.20921. Epub 2011 Aug 24. Genes Chromosomes Cancer. 2011. PMID: 21987445
64 results