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Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidović D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2354-9. doi: 10.1016/j.bmcl.2008.09.066. Epub 2008 Sep 20. Bioorg Med Chem Lett. 2009. PMID: 19303288 Free PMC article.
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, Vidović D, Schürer S, Branden L, Davis RE, Staudt LM, Inglese J, Austin CP, Landry DW, Smith DH, Auld DS. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. doi: 10.1016/j.bmcl.2007.10.100. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18024113 Free PMC article.
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Xie Y, Liu Y, Gong G, Rinderspacher A, Deng SX, Smith DH, Toebben U, Tzilianos E, Branden L, Vidović D, Chung C, Schürer S, Tautz L, Landry DW. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2008 May 1;18(9):2840-4. doi: 10.1016/j.bmcl.2008.03.079. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18434147 Free PMC article.
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW. Rinderspacher A, et al. Among authors: chung c. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1715-7. doi: 10.1016/j.bmcl.2009.01.087. Epub 2009 Jan 30. Bioorg Med Chem Lett. 2009. PMID: 19243939 Free PMC article.
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L. Vang T, et al. Among authors: chung c. J Med Chem. 2011 Jan 27;54(2):562-71. doi: 10.1021/jm101004d. Epub 2010 Dec 29. J Med Chem. 2011. PMID: 21190368 Free PMC article.
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.
Vidović D, Xie Y, Rinderspacher A, Deng SX, Landry DW, Chung C, Smith DH, Tautz L, Schürer SC. Vidović D, et al. Among authors: chung c. J Comput Aided Mol Des. 2011 Sep;25(9):873-83. doi: 10.1007/s10822-011-9469-2. Epub 2011 Sep 9. J Comput Aided Mol Des. 2011. PMID: 21904909 Free PMC article.
Drug target ontology to classify and integrate drug discovery data.
Lin Y, Mehta S, Küçük-McGinty H, Turner JP, Vidovic D, Forlin M, Koleti A, Nguyen DT, Jensen LJ, Guha R, Mathias SL, Ursu O, Stathias V, Duan J, Nabizadeh N, Chung C, Mader C, Visser U, Yang JJ, Bologa CG, Oprea TI, Schürer SC. Lin Y, et al. Among authors: chung c. J Biomed Semantics. 2017 Nov 9;8(1):50. doi: 10.1186/s13326-017-0161-x. J Biomed Semantics. 2017. PMID: 29122012 Free PMC article.
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A. Keenan AB, et al. Among authors: chung c. Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29. Cell Syst. 2018. PMID: 29199020 Free PMC article. Review.
7,935 results