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Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.
Gennero I, Laurencin-Dalicieux S, Conte-Auriol F, Briand-Mésange F, Laurencin D, Rue J, Beton N, Malet N, Mus M, Tokumura A, Bourin P, Vico L, Brunel G, Oreffo RO, Chun J, Salles JP. Gennero I, et al. Among authors: chun j. Bone. 2011 Sep;49(3):395-403. doi: 10.1016/j.bone.2011.04.018. Epub 2011 May 1. Bone. 2011. PMID: 21569876 Free PMC article.
Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.
Alioli CA, Demesmay L, Laurencin-Dalacieux S, Beton N, Farlay D, Follet H, Saber A, Duboeuf F, Chun J, Rivera R, Bouvard D, Machuca-Gayet I, Salles JP, Gennero I, Peyruchaud O. Alioli CA, et al. Among authors: chun j. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158715. doi: 10.1016/j.bbalip.2020.158715. Epub 2020 Apr 21. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32330664 Free article.
Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.
David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RL, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. David M, et al. Among authors: chun j. J Biol Chem. 2014 Mar 7;289(10):6551-6564. doi: 10.1074/jbc.M113.533232. Epub 2014 Jan 15. J Biol Chem. 2014. PMID: 24429286 Free PMC article.
LPA1 receptor activation promotes renal interstitial fibrosis.
Pradère JP, Klein J, Grès S, Guigné C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP. Pradère JP, et al. Among authors: chun j. J Am Soc Nephrol. 2007 Dec;18(12):3110-8. doi: 10.1681/ASN.2007020196. Epub 2007 Nov 14. J Am Soc Nephrol. 2007. PMID: 18003779
Absence of LPA1 signaling results in defective cortical development.
Estivill-Torrús G, Llebrez-Zayas P, Matas-Rico E, Santín L, Pedraza C, De Diego I, Del Arco I, Fernández-Llebrez P, Chun J, De Fonseca FR. Estivill-Torrús G, et al. Among authors: chun j. Cereb Cortex. 2008 Apr;18(4):938-50. doi: 10.1093/cercor/bhm132. Epub 2007 Jul 26. Cereb Cortex. 2008. PMID: 17656621
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.
Matas-Rico E, García-Diaz B, Llebrez-Zayas P, López-Barroso D, Santín L, Pedraza C, Smith-Fernández A, Fernández-Llebrez P, Tellez T, Redondo M, Chun J, De Fonseca FR, Estivill-Torrús G. Matas-Rico E, et al. Among authors: chun j. Mol Cell Neurosci. 2008 Nov;39(3):342-55. doi: 10.1016/j.mcn.2008.07.014. Epub 2008 Jul 29. Mol Cell Neurosci. 2008. PMID: 18708146 Free PMC article.
Necessity of lysophosphatidic acid receptor 1 for development of arthritis.
Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T. Miyabe Y, et al. Among authors: chun j. Arthritis Rheum. 2013 Aug;65(8):2037-47. doi: 10.1002/art.37991. Arthritis Rheum. 2013. PMID: 23666827 Free article.
2,367 results