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Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K. Serrao A, et al. Among authors: chumanevich aa. Oncogene. 2018 Aug;37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21. Oncogene. 2018. PMID: 29780169 Free PMC article.
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.
McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV. McDermott MS, et al. Among authors: chumanevich aa. Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894. Oncotarget. 2017. PMID: 28147342 Free PMC article.
CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.
Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. Liang J, et al. Among authors: chumanevich aa. Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583. Epub 2018 Sep 5. Cancer Res. 2018. PMID: 30185549 Free PMC article.
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Ding X, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119. doi: 10.1073/pnas.2201073119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914167 Free PMC article.
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
Li J, Hilimire TA, Yueying L, Wang L, Liang J, Győrffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. Li J, et al. Among authors: chumanevich aa. J Clin Invest. 2024 Mar 28:e176709. doi: 10.1172/JCI176709. Online ahead of print. J Clin Invest. 2024. PMID: 38546787 Free article.
44 results