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PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation.
Farabaugh KT, Krokowski D, Guan BJ, Gao Z, Gao XH, Wu J, Jobava R, Ray G, de Jesus TJ, Bianchi MG, Chukwurah E, Bussolati O, Kilberg M, Buchner DA, Sen GC, Cotton C, McDonald C, Longworth M, Ramakrishnan P, Hatzoglou M. Farabaugh KT, et al. Among authors: chukwurah e. Elife. 2020 Mar 16;9:e52241. doi: 10.7554/eLife.52241. Elife. 2020. PMID: 32175843 Free PMC article.
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Jobava R, et al. Among authors: chukwurah e. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. Mol Cell. 2021. PMID: 34686314 Free PMC article.
Counteracting epigenetic mechanisms regulate the structural development of neuronal circuitry in human neurons.
Cheon S, Culver AM, Bagnell AM, Ritchie FD, Vacharasin JM, McCord MM, Papendorp CM, Chukwurah E, Smith AJ, Cowen MH, Moreland TA, Ghate PS, Davis SW, Liu JS, Lizarraga SB. Cheon S, et al. Among authors: chukwurah e. Mol Psychiatry. 2022 Apr;27(4):2291-2303. doi: 10.1038/s41380-022-01474-1. Epub 2022 Feb 24. Mol Psychiatry. 2022. PMID: 35210569 Free PMC article.
13 results