Chu WK - Search Results

1

MUS81 promotes common fragile site expression.

Ying S, Minocherhomji S, Chan KL, Palmai-Pallag T, Chu WK, Wass T, Mankouri HW, Liu Y, Hickson ID. Ying S, et al. Among authors: chu wk. Nat Cell Biol. 2013 Aug;15(8):1001-7. doi: 10.1038/ncb2773. Epub 2013 Jun 30. Nat Cell Biol. 2013. PMID: 23811685

2

RecQ helicases: multifunctional genome caretakers.

Chu WK, Hickson ID. Chu WK, et al. Nat Rev Cancer. 2009 Sep;9(9):644-54. doi: 10.1038/nrc2682. Epub 2009 Aug 6. Nat Rev Cancer. 2009. PMID: 19657341 Review.

3

BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.

Chu WK, Hanada K, Kanaar R, Hickson ID. Chu WK, et al. Oncogene. 2010 Aug 19;29(33):4705-14. doi: 10.1038/onc.2010.214. Epub 2010 Jun 7. Oncogene. 2010. PMID: 20531307

4

A novel antirecombinase gains PARIty.

Mankouri HW, Chu WK, Hickson ID. Mankouri HW, et al. Among authors: chu wk. Mol Cell. 2012 Jan 13;45(1):6-7. doi: 10.1016/j.molcel.2011.12.015. Mol Cell. 2012. PMID: 22244326 Free article.

5

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID. Nguyen GH, et al. Among authors: chu wk. Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016. Chem Biol. 2013. PMID: 23352139 Free PMC article.

6

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS. Fugger K, et al. Among authors: chu wk. Nat Commun. 2013;4:1423. doi: 10.1038/ncomms2395. Nat Commun. 2013. PMID: 23361013 Free article.

7

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ. Rosenthal AS, et al. Among authors: chu wk. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6. doi: 10.1016/j.bmcl.2013.08.025. Epub 2013 Aug 13. Bioorg Med Chem Lett. 2013. PMID: 24012121 Free PMC article.

8

FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.

Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID. Simandlova J, et al. Among authors: chu wk. J Biol Chem. 2013 Nov 22;288(47):34168-34180. doi: 10.1074/jbc.M113.484493. Epub 2013 Oct 9. J Biol Chem. 2013. PMID: 24108124 Free PMC article.

9

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.

Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID. Chu WK, et al. Nat Commun. 2015 Jan 14;6:5931. doi: 10.1038/ncomms6931. Nat Commun. 2015. PMID: 25585578 Free article.

10

FBH1 Catalyzes Regression of Stalled Replication Forks.

Fugger K, Mistrik M, Neelsen KJ, Yao Q, Zellweger R, Kousholt AN, Haahr P, Chu WK, Bartek J, Lopes M, Hickson ID, Sørensen CS. Fugger K, et al. Among authors: chu wk. Cell Rep. 2015 Mar 17;10(10):1749-1757. doi: 10.1016/j.celrep.2015.02.028. Epub 2015 Mar 12. Cell Rep. 2015. PMID: 25772361 Free article.

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