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NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, Krizova A, Kirpalani A, Gregorieff A, Ni R, Chan K, Gill MK, Attisano L, Wrana JL, Yuen DA. Zhang T, et al. Among authors: christova t. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028. doi: 10.1126/scitranslmed.aaz4028. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320001
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.
Song S, Christova T, Perusini S, Alizadeh S, Bao RY, Miller BW, Hurren R, Jitkova Y, Gronda M, Isaac M, Joseph B, Subramaniam R, Aman A, Chau A, Hogge DE, Weir SJ, Kasper J, Schimmer AD, Al-awar R, Wrana JL, Attisano L. Song S, et al. Among authors: christova t. Cancer Res. 2011 Dec 15;71(24):7628-39. doi: 10.1158/0008-5472.CAN-11-2745. Epub 2011 Oct 18. Cancer Res. 2011. PMID: 22009536 Clinical Trial.
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.
Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L. Gill MK, et al. Among authors: christova t. Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2. Nat Commun. 2018. PMID: 30158528 Free PMC article.
34 results