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Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.
Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Knipe RS, et al. Among authors: christoffersen c. Am J Respir Cell Mol Biol. 2022 Jan;66(1):38-52. doi: 10.1165/rcmb.2020-0408OC. Am J Respir Cell Mol Biol. 2022. PMID: 34343038 Free PMC article.
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B. Christoffersen C, et al. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. doi: 10.1073/pnas.1103187108. Epub 2011 May 23. Proc Natl Acad Sci U S A. 2011. PMID: 21606363 Free PMC article.
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Christensen PM, et al. Among authors: christoffersen c. FASEB J. 2016 Jun;30(6):2351-9. doi: 10.1096/fj.201500064. Epub 2016 Mar 8. FASEB J. 2016. PMID: 26956418 Free PMC article.
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.-Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, K., Nielsen, L B …
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacer …
Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature.
Del Gaudio I, Sreckovic I, Zardoya-Laguardia P, Bernhart E, Christoffersen C, Frank S, Marsche G, Illanes SE, Wadsack C. Del Gaudio I, et al. Among authors: christoffersen c. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158632. doi: 10.1016/j.bbalip.2020.158632. Epub 2020 Jan 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31954174 Free article.
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Velagapudi S, Rohrer L, Poti F, Feuerborn R, Perisa D, Wang D, Panteloglou G, Potapenko A, Yalcinkaya M, Hülsmeier AJ, Hesse B, Lukasz A, Liu M, Parks JS, Christoffersen C, Stoffel M, Simoni M, Nofer JR, von Eckardstein A. Velagapudi S, et al. Among authors: christoffersen c. Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):e468-e479. doi: 10.1161/ATVBAHA.121.316725. Epub 2021 Aug 19. Arterioscler Thromb Vasc Biol. 2021. PMID: 34407633 Free PMC article.
183 results