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Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.
Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. Kurnik M, et al. Among authors: christiansen g. Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197194 Free article.
Multiple roles of heparin in the aggregation of p25α.
Nielsen SB, Yde P, Giehm L, Sundbye S, Christiansen G, Mathiesen J, Jensen MH, Jensen PH, Otzen DE. Nielsen SB, et al. Among authors: christiansen g. J Mol Biol. 2012 Aug 24;421(4-5):601-15. doi: 10.1016/j.jmb.2012.01.050. Epub 2012 Feb 3. J Mol Biol. 2012. PMID: 22326478
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TP, Otzen DE. Lorenzen N, et al. Among authors: christiansen g. J Am Chem Soc. 2014 Mar 12;136(10):3859-68. doi: 10.1021/ja411577t. Epub 2014 Feb 28. J Am Chem Soc. 2014. PMID: 24527756
How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.
Lorenzen N, Nielsen SB, Yoshimura Y, Vad BS, Andersen CB, Betzer C, Kaspersen JD, Christiansen G, Pedersen JS, Jensen PH, Mulder FA, Otzen DE. Lorenzen N, et al. Among authors: christiansen g. J Biol Chem. 2014 Aug 1;289(31):21299-310. doi: 10.1074/jbc.M114.554667. Epub 2014 Jun 6. J Biol Chem. 2014. PMID: 24907278 Free PMC article.
Antibodies against the C-terminus of α-synuclein modulate its fibrillation.
Sahin C, Lorenzen N, Lemminger L, Christiansen G, Møller IM, Vesterager LB, Pedersen LØ, Fog K, Kallunki P, Otzen DE. Sahin C, et al. Among authors: christiansen g. Biophys Chem. 2017 Jan;220:34-41. doi: 10.1016/j.bpc.2016.11.002. Epub 2016 Nov 10. Biophys Chem. 2017. PMID: 27863716
Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity.
Mohammad-Beigi H, Aliakbari F, Sahin C, Lomax C, Tawfike A, Schafer NP, Amiri-Nowdijeh A, Eskandari H, Møller IM, Hosseini-Mazinani M, Christiansen G, Ward JL, Morshedi D, Otzen DE. Mohammad-Beigi H, et al. Among authors: christiansen g. J Biol Chem. 2019 Mar 15;294(11):4215-4232. doi: 10.1074/jbc.RA118.005723. Epub 2019 Jan 17. J Biol Chem. 2019. PMID: 30655291 Free PMC article.
339 results