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Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: christiansen e. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.
Hudson BD, Due-Hansen ME, Christiansen E, Hansen AM, Mackenzie AE, Murdoch H, Pandey SK, Ward RJ, Marquez R, Tikhonova IG, Ulven T, Milligan G. Hudson BD, et al. Among authors: christiansen e. J Biol Chem. 2013 Jun 14;288(24):17296-312. doi: 10.1074/jbc.M113.455337. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589301 Free PMC article.
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T. Christiansen E, et al. ACS Med Chem Lett. 2013 May 9;4(5):441-445. doi: 10.1021/ml4000673. Epub 2013 Apr 8. ACS Med Chem Lett. 2013. PMID: 23687558 Free PMC article.
Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands.
Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Hudson BD, et al. Among authors: christiansen e. Mol Pharmacol. 2014 Aug;86(2):200-10. doi: 10.1124/mol.114.093294. Epub 2014 May 28. Mol Pharmacol. 2014. PMID: 24870406 Free article.
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T. Hansen SV, et al. Among authors: christiansen e. J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15. J Med Chem. 2016. PMID: 26928019
744 results