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2016 1
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2020 5
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2022 7
2023 5
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27 results

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Page 1
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
Steinebach C, Bricelj A, Murgai A, Sosič I, Bischof L, Ng YLD, Heim C, Maiwald S, Proj M, Voget R, Feller F, Košmrlj J, Sapozhnikova V, Schmidt A, Zuleeg MR, Lemnitzer P, Mertins P, Hansen FK, Gütschow M, Krönke J, Hartmann MD. Steinebach C, et al. J Med Chem. 2023 Nov 9;66(21):14513-14543. doi: 10.1021/acs.jmedchem.3c00851. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902300 Free PMC article.
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers.
Vu LP, Diehl CJ, Casement R, Bond AG, Steinebach C, Strašek N, Bricelj A, Perdih A, Schnakenburg G, Sosič I, Ciulli A, Gütschow M. Vu LP, et al. Among authors: steinebach c. J Med Chem. 2023 Sep 28;66(18):12776-12811. doi: 10.1021/acs.jmedchem.3c00434. Epub 2023 Sep 14. J Med Chem. 2023. PMID: 37708384 Free PMC article.
Development of the first non-hydroxamate selective HDAC6 degraders.
Keuler T, König B, Bückreiß N, Kraft FB, König P, Schäker-Hübner L, Steinebach C, Bendas G, Gütschow M, Hansen FK. Keuler T, et al. Among authors: steinebach c. Chem Commun (Camb). 2022 Oct 4;58(79):11087-11090. doi: 10.1039/d2cc03712b. Chem Commun (Camb). 2022. PMID: 36098075
Targeting the deubiquitinase USP7 for degradation with PROTACs.
Murgai A, Sosič I, Gobec M, Lemnitzer P, Proj M, Wittenburg S, Voget R, Gütschow M, Krönke J, Steinebach C. Murgai A, et al. Among authors: steinebach c. Chem Commun (Camb). 2022 Aug 4;58(63):8858-8861. doi: 10.1039/d2cc02094g. Chem Commun (Camb). 2022. PMID: 35852517 Free PMC article.
Encoding BRAF inhibitor functions in protein degraders.
Miller DSJ, Voell SA, Sosič I, Proj M, Rossanese OW, Schnakenburg G, Gütschow M, Collins I, Steinebach C. Miller DSJ, et al. Among authors: steinebach c. RSC Med Chem. 2022 May 5;13(6):731-736. doi: 10.1039/d2md00064d. eCollection 2022 Jun 22. RSC Med Chem. 2022. PMID: 35814929 Free PMC article.
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng YLD, Ramberger E, Bohl SR, Dolnik A, Steinebach C, Conrad T, Müller S, Popp O, Kull M, Haji M, Gütschow M, Döhner H, Walther W, Keller U, Bullinger L, Mertins P, Krönke J. Ng YLD, et al. Among authors: steinebach c. Nat Commun. 2022 Feb 23;13(1):1009. doi: 10.1038/s41467-022-28515-1. Nat Commun. 2022. PMID: 35197447 Free PMC article.
27 results