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Challenges and opportunities for non-antibody scaffold drugs.
Vazquez-Lombardi R, Phan TG, Zimmermann C, Lowe D, Jermutus L, Christ D. Vazquez-Lombardi R, et al. Among authors: christ d. Drug Discov Today. 2015 Oct;20(10):1271-83. doi: 10.1016/j.drudis.2015.09.004. Epub 2015 Sep 7. Drug Discov Today. 2015. PMID: 26360055 Free article. Review.
Expression of high-affinity human antibody fragments in bacteria.
Rouet R, Lowe D, Dudgeon K, Roome B, Schofield P, Langley D, Andrews J, Whitfeld P, Jermutus L, Christ D. Rouet R, et al. Among authors: christ d. Nat Protoc. 2012 Feb 2;7(2):364-73. doi: 10.1038/nprot.2011.448. Nat Protoc. 2012. PMID: 22301775
Stability engineering of the human antibody repertoire.
Rouet R, Lowe D, Christ D. Rouet R, et al. Among authors: christ d. FEBS Lett. 2014 Jan 21;588(2):269-77. doi: 10.1016/j.febslet.2013.11.029. Epub 2013 Nov 28. FEBS Lett. 2014. PMID: 24291820 Free article. Review.
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Sabouri Z, et al. Among authors: christ d. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821781 Free PMC article. Clinical Trial.
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.
Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R. Butt D, et al. Among authors: christ d. Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12. Immunity. 2015. PMID: 25979420 Free article.
Circumventing the stability-function trade-off in an engineered FN3 domain.
Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM. Porebski BT, et al. Among authors: christ d. Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046. Protein Eng Des Sel. 2016. PMID: 27578887 Free PMC article.
IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.
Corpuz TM, Vazquez-Lombardi R, Luong JK, Warren J, Stolp J, Christ D, King C, Brink R, Sprent J, Webster KE. Corpuz TM, et al. Among authors: christ d. J Immunol. 2017 Oct 1;199(7):2366-2376. doi: 10.4049/jimmunol.1700335. Epub 2017 Aug 23. J Immunol. 2017. PMID: 28835458
191 results