Chou TF - Search Results

1

Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11.

Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Perez C, Yang Y, Peng J, Cohen SM, Chou TF, Hilton ST, Deshaies RJ. Li J, et al. Among authors: chou tf. Cell Chem Biol. 2018 Nov 15;25(11):1350-1358.e9. doi: 10.1016/j.chembiol.2018.07.012. Epub 2018 Aug 23. Cell Chem Biol. 2018. PMID: 30146242 Free PMC article.

2

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.

Chou TF, Deshaies RJ. Chou TF, et al. J Biol Chem. 2011 May 13;286(19):16546-54. doi: 10.1074/jbc.M110.215319. Epub 2011 Feb 22. J Biol Chem. 2011. PMID: 21343295 Free PMC article.

3

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Chou TF, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383145 Free PMC article.

4

Development of p97 AAA ATPase inhibitors.

Chou TF, Deshaies RJ. Chou TF, et al. Autophagy. 2011 Sep;7(9):1091-2. doi: 10.4161/auto.7.9.16489. Epub 2011 Sep 1. Autophagy. 2011. PMID: 21606684 Free PMC article.

5

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312. doi: 10.1002/cmdc.201200520. Epub 2013 Jan 11. ChemMedChem. 2013. PMID: 23316025 Free PMC article.

6

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Chou TF, et al. J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27. J Mol Biol. 2014. PMID: 24878061 Free PMC article.

7

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM. Perez C, et al. Among authors: chou tf. J Med Chem. 2017 Feb 23;60(4):1343-1361. doi: 10.1021/acs.jmedchem.6b01379. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28191850 Free PMC article.

8

Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Perez C, Li J, Parlati F, Rouffet M, Ma Y, Zhou HJ, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM. Perez C, et al. Among authors: chou tf. J Med Chem. 2017 Apr 13;60(7):3217. doi: 10.1021/acs.jmedchem.7b00390. Epub 2017 Mar 22. J Med Chem. 2017. PMID: 28328205 No abstract available.

9

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D. Nakasone MA, et al. Among authors: chou tf. Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. Epub 2017 Nov 16. Structure. 2017. PMID: 29153505 Free PMC article.

10

Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors.

Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J. Bastola P, et al. Among authors: chou tf. Cell Death Discov. 2017 Nov 6;3:17065. doi: 10.1038/cddiscovery.2017.65. eCollection 2017. Cell Death Discov. 2017. PMID: 29367883 Free PMC article.

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