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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: choi km. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
Zinc deficiency primes the lung for ventilator-induced injury.
Boudreault F, Pinilla-Vera M, Englert JA, Kho AT, Isabelle C, Arciniegas AJ, Barragan-Bradford D, Quintana C, Amador-Munoz D, Guan J, Choi KM; MICU Registry; Sholl L, Hurwitz S, Tschumperlin DJ, Baron RM. Boudreault F, et al. Among authors: choi km. JCI Insight. 2017 Jun 2;2(11):e86507. doi: 10.1172/jci.insight.86507. eCollection 2017 Jun 2. JCI Insight. 2017. PMID: 28570269 Free PMC article.
Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.
Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Dieffenbach PB, et al. Among authors: choi km. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28642262 Free PMC article.
Aging and anatomical variations in lung tissue stiffness.
Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ. Sicard D, et al. Among authors: choi km. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L946-L955. doi: 10.1152/ajplung.00415.2017. Epub 2018 Feb 22. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29469613 Free PMC article.
RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation.
Oh RS, Haak AJ, Smith KMJ, Ligresti G, Choi KM, Xie T, Wang S, Walters PR, Thompson MA, Freeman MR, Manlove LJ, Chu VM, Feghali-Bostwick C, Roden AC, Schymeinsky J, Pabelick CM, Prakash YS, Vassallo R, Tschumperlin DJ. Oh RS, et al. Among authors: choi km. J Cell Sci. 2018 May 15;131(10):jcs209932. doi: 10.1242/jcs.209932. J Cell Sci. 2018. PMID: 29678906 Free PMC article.
622 results