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A consensus set of genetic vulnerabilities to ATR inhibition.
Hustedt N, Álvarez-Quilón A, McEwan A, Yuan JY, Cho T, Koob L, Hart T, Durocher D. Hustedt N, et al. Among authors: cho t. Open Biol. 2019 Sep 27;9(9):190156. doi: 10.1098/rsob.190156. Epub 2019 Sep 11. Open Biol. 2019. PMID: 31506018 Free PMC article.
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Canny MD, et al. Among authors: cho t. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. Nat Biotechnol. 2018. PMID: 29176614 Free PMC article.
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Álvarez-Quilón A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Muñoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Álvarez-Quilón A, et al. Among authors: cho t. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. Mol Cell. 2020. PMID: 32516598 Free PMC article.
A Genetic Map of the Response to DNA Damage in Human Cells.
Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Olivieri M, et al. Among authors: cho t. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. Cell. 2020. PMID: 32649862 Free PMC article.
Response to the Letter to the Editor Concerning the Article "Rotenone Increases Isoniazid Toxicity but Does Not Cause Liver Injury: Implications for the Hypothesis That Inhibition of the Mitochondrial Electron Transport Chain Is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury" by Bernard Fromenty.
Cho T, Uetrecht J. Cho T, et al. Chem Res Toxicol. 2020 Jan 21;33(1):5-6. doi: 10.1021/acs.chemrestox.9b00436. Epub 2019 Dec 17. Chem Res Toxicol. 2020. PMID: 31820941 No abstract available.
1,308 results