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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE. de Alwis R, et al. Among authors: chivukula p. Mol Ther. 2021 Jun 2;29(6):1970-1983. doi: 10.1016/j.ymthe.2021.04.001. Epub 2021 Apr 5. Mol Ther. 2021. PMID: 33823303 Free PMC article.
Systemic delivery of factor IX messenger RNA for protein replacement therapy.
Ramaswamy S, Tonnu N, Tachikawa K, Limphong P, Vega JB, Karmali PP, Chivukula P, Verma IM. Ramaswamy S, et al. Among authors: chivukula p. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950. doi: 10.1073/pnas.1619653114. Epub 2017 Feb 15. Proc Natl Acad Sci U S A. 2017. PMID: 28202722 Free PMC article.
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation.
Latorre J, Díaz-Trelles R, Comas F, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Ortega F, Castells-Nobau A, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, López M, Giralt M, Fernández-Real JM, Moreno-Navarrete JM. Latorre J, et al. Among authors: chivukula p. Mol Ther Nucleic Acids. 2022 Aug 5;29:599-613. doi: 10.1016/j.omtn.2022.08.003. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090751 Free PMC article.
Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM. Milbank E, et al. Among authors: chivukula p. Pharmacol Res. 2023 Jan;187:106562. doi: 10.1016/j.phrs.2022.106562. Epub 2022 Nov 21. Pharmacol Res. 2023. PMID: 36410673 Free article.
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine.
Ong EZ, Yee JX, Ooi JSG, Syenina A, de Alwis R, Chen S, Sim JXY, Kalimuddin S, Leong YS, Chan YFZ, Sekulovich R, Sullivan BM, Lindert K, Sullivan SB, Chivukula P, Hughes SG, Low JG, Ooi EE, Chan KR. Ong EZ, et al. Among authors: chivukula p. NPJ Vaccines. 2022 Nov 28;7(1):154. doi: 10.1038/s41541-022-00573-y. NPJ Vaccines. 2022. PMID: 36443317 Free PMC article.
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine.
Low JG, de Alwis R, Chen S, Kalimuddin S, Leong YS, Mah TKL, Yuen N, Tan HC, Zhang SL, Sim JXY, Chan YFZ, Syenina A, Yee JX, Ong EZ, Sekulovich R, Sullivan BB, Lindert K, Sullivan SM, Chivukula P, Hughes SG, Ooi EE. Low JG, et al. Among authors: chivukula p. NPJ Vaccines. 2022 Dec 13;7(1):161. doi: 10.1038/s41541-022-00590-x. NPJ Vaccines. 2022. PMID: 36513697 Free PMC article.
Engineered tRNAs suppress nonsense mutations in cells and in vivo.
Albers S, Allen EC, Bharti N, Davyt M, Joshi D, Perez-Garcia CG, Santos L, Mukthavaram R, Delgado-Toscano MA, Molina B, Kuakini K, Alayyoubi M, Park KJ, Acharya G, Gonzalez JA, Sagi A, Birket SE, Tearney GJ, Rowe SM, Manfredi C, Hong JS, Tachikawa K, Karmali P, Matsuda D, Sorscher EJ, Chivukula P, Ignatova Z. Albers S, et al. Among authors: chivukula p. Nature. 2023 Jun;618(7966):842-848. doi: 10.1038/s41586-023-06133-1. Epub 2023 May 31. Nature. 2023. PMID: 37258671 Free PMC article.
26 results