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Development of an mRNA replacement therapy for phenylketonuria.
Perez-Garcia CG, Diaz-Trelles R, Vega JB, Bao Y, Sablad M, Limphong P, Chikamatsu S, Yu H, Taylor W, Karmali PP, Tachikawa K, Chivukula P. Perez-Garcia CG, et al. Among authors: chivukula p. Mol Ther Nucleic Acids. 2022 Feb 28;28:87-98. doi: 10.1016/j.omtn.2022.02.020. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35356682 Free PMC article.
Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.
Rajappan K, Tanis SP, Mukthavaram R, Roberts S, Nguyen M, Tachikawa K, Sagi A, Sablad M, Limphong P, Leu A, Yu H, Chivukula P, Payne JE, Karmali P. Rajappan K, et al. Among authors: chivukula p. J Med Chem. 2020 Nov 12;63(21):12992-13012. doi: 10.1021/acs.jmedchem.0c01407. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119286
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez JA, Dam T, Kim JH, Vega JB, Sablad M, Karmali PP, Tachikawa K, Chivukula P. Diaz-Trelles R, et al. Among authors: chivukula p. Mol Genet Metab Rep. 2022 May 14;32:100882. doi: 10.1016/j.ymgmr.2022.100882. eCollection 2022 Sep. Mol Genet Metab Rep. 2022. PMID: 35600090 Free PMC article.
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M. Hirunagi T, et al. Among authors: chivukula p. Mol Ther Nucleic Acids. 2021 Feb 15;24:1-10. doi: 10.1016/j.omtn.2021.02.007. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33738134 Free PMC article.
Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models.
Perley CC, Brocato RL, Wu H, Bausch C, Karmali PP, Vega JB, Cohen MV, Somerville B, Kwilas SA, Principe LM, Shamblin J, Chivukula P, Sullivan E, Hooper JW. Perley CC, et al. Among authors: chivukula p. Front Microbiol. 2020 May 7;11:832. doi: 10.3389/fmicb.2020.00832. eCollection 2020. Front Microbiol. 2020. PMID: 32508764 Free PMC article.
CD8+ T cells mediate protection against Zika virus induced by an NS3-based vaccine.
Elong Ngono A, Syed T, Nguyen AV, Regla-Nava JA, Susantono M, Spasova D, Aguilar A, West M, Sparks J, Gonzalez A, Branche E, DeHart JL, Vega JB, Karmali PP, Chivukula P, Kamrud K, Aliahmad P, Wang N, Shresta S. Elong Ngono A, et al. Among authors: chivukula p. Sci Adv. 2020 Nov 4;6(45):eabb2154. doi: 10.1126/sciadv.abb2154. Print 2020 Nov. Sci Adv. 2020. PMID: 33148638 Free PMC article.
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