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Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight.
Cell Metab. 2023 May 2;35(5):875-886.e5. doi: 10.1016/j.cmet.2023.03.014. Epub 2023 Apr 14.
Cell Metab. 2023.
PMID: 37060902
Free article.
A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
Li RJW, Chiu JFM, Bruce K, Zhang SY, Barros DR, Yue JTY, Lam TKT.
Li RJW, et al. Among authors: chiu jfm.
J Biol Chem. 2023 May;299(5):104633. doi: 10.1016/j.jbc.2023.104633. Epub 2023 Mar 23.
J Biol Chem. 2023.
PMID: 36963496
Free PMC article.
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Acute Activation of GFRAL in the Area Postrema Contributes to Glucose Regulation Independent of Weight.
Zhang SY, Danaei Z, Bruce K, Chiu JFM, Lam TKT.
Zhang SY, et al. Among authors: chiu jfm.
Diabetes. 2024 Mar 1;73(3):426-433. doi: 10.2337/db23-0705.
Diabetes. 2024.
PMID: 38064571
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