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Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.
Jaroensuk J, Wong YH, Zhong W, Liew CW, Maenpuen S, Sahili AE, Atichartpongkul S, Chionh YH, Nah Q, Thongdee N, McBee ME, Prestwich EG, DeMott MS, Chaiyen P, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M. Jaroensuk J, et al. Among authors: chionh yh. RNA. 2019 Nov;25(11):1481-1496. doi: 10.1261/rna.066746.118. Epub 2019 Aug 9. RNA. 2019. PMID: 31399541 Free PMC article.
Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M. Jaroensuk J, et al. Among authors: chionh yh. Nucleic Acids Res. 2016 Dec 15;44(22):10834-10848. doi: 10.1093/nar/gkw870. Epub 2016 Sep 28. Nucleic Acids Res. 2016. PMID: 27683218 Free PMC article.
Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.
Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P. Zhong W, et al. Among authors: chionh yh. ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4. ACS Infect Dis. 2019. PMID: 30682246
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC. Zhong W, et al. Among authors: chionh yh. J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29. J Med Chem. 2019. PMID: 31442049 Free PMC article.
Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides.
Hia F, Chionh YH, Pang YL, DeMott MS, McBee ME, Dedon PC. Hia F, et al. Among authors: chionh yh. Nucleic Acids Res. 2015 Mar 11;43(5):e32. doi: 10.1093/nar/gku1317. Epub 2014 Dec 24. Nucleic Acids Res. 2015. PMID: 25539917 Free PMC article.
21 results