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PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS Jr, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP. Celada LJ, et al. Among authors: chioma os. Sci Transl Med. 2018 Sep 26;10(460):eaar8356. doi: 10.1126/scitranslmed.aar8356. Sci Transl Med. 2018. PMID: 30257954 Free PMC article.
Role of Microbial Agents in Pulmonary Fibrosis
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Chioma OS, Drake WP. Chioma OS, et al. Yale J Biol Med. 2017 Jun 23;90(2):219-227. eCollection 2017 Jun. Yale J Biol Med. 2017. PMID: 28656009 Free PMC article. Review.
Role of the Microbiome in Interstitial Lung Diseases.
Chioma OS, Hesse LE, Chapman A, Drake WP. Chioma OS, et al. Front Med (Lausanne). 2021 Jan 28;8:595522. doi: 10.3389/fmed.2021.595522. eCollection 2021. Front Med (Lausanne). 2021. PMID: 33604346 Free PMC article. Review.
Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease.
Chioma OS, Mallott E, Shah-Gandhi B, Wiggins Z, Langford M, Lancaster AW, Gelbard A, Wu H, Johnson JE, Lancaster L, Wilfong EM, Crofford LJ, Montgomery CG, Van Kaer L, Bordenstein S, Newcomb DC, Drake WP. Chioma OS, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.15.528630. doi: 10.1101/2023.02.15.528630. bioRxiv. 2023. PMID: 36824732 Free PMC article. Updated. Preprint.
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice.
Chioma OS, Mallott EK, Chapman A, Van Amburg JC, Wu H, Shah-Gandhi B, Dey N, Kirkland ME, Blanca Piazuelo M, Johnson J, Bernard GR, Bodduluri SR, Davison S, Haribabu B, Bordenstein SR, Drake WP. Chioma OS, et al. Commun Biol. 2022 Dec 22;5(1):1401. doi: 10.1038/s42003-022-04357-x. Commun Biol. 2022. PMID: 36543914 Free PMC article.