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Metabolic biomarkers significantly enhance the prediction of HBV-related ACLF occurrence and outcomes.
Zhang Y, Tan W, Wang X, Zheng X, Huang Y, Li B, Meng Z, Gao Y, Qian Z, Liu F, Lu X, Shi Y, Shang J, Yan H, Zheng Y, Zhang W, Gu W, Qiao L, Deng G, Zhou Y, Hou Y, Zhang Q, Xiong S, Liu J, Duan L, Chen R, Chen J, Jiang X, Luo S, Chen Y, Jiang C, Zhao J, Ji L, Mei X, Li J, Li T, Zheng R, Zhou X, Ren H, Cheng X, Guo L, Li H; Chinese (Acute on) Chronic Liver Failure Consortium (Ch-CLIF.C). Zhang Y, et al. J Hepatol. 2023 Nov;79(5):1159-1171. doi: 10.1016/j.jhep.2023.07.011. Epub 2023 Jul 29. J Hepatol. 2023. PMID: 37517452
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a clinical syndrome associated with high short-term mortality in patients with chronic liver disease. ...CLINICAL TRIAL NUMBER: NCT02457637 and NCT03641872. IMPACT AND …
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a clinical syndrome associated with high short-t …
Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure Patients: Short-Term Outcomes and Antifungal Options.
Chen D, Qian Z, Su H, Meng Z, Lv J, Huang Y, Gao Y, Liu J, Zhao C, Gao H, Chen Y, Xia J, Peng L, Han T, Li H, Zheng X, Wang X, Lu X, Shi Y, Hu J, Chen J. Chen D, et al. Infect Dis Ther. 2021 Dec;10(4):2525-2538. doi: 10.1007/s40121-021-00524-5. Epub 2021 Sep 1. Infect Dis Ther. 2021. PMID: 34468963 Free PMC article.
INTRODUCTION: Acute-on-chronic liver failure (ACLF) patients are susceptible to invasive fungal infections. ...CONCLUSION: Presence of IPA increases the short-term mortality of ACLF patients mainly due to respiratory failure. An optimal voricona …
INTRODUCTION: Acute-on-chronic liver failure (ACLF) patients are susceptible to invasive fungal infections. ...C …
Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis.
Wang T, Tan W, Wang X, Zheng X, Huang Y, Li B, Meng Z, Gao Y, Qian Z, Liu F, Lu X, Yan H, Zheng Y, Zhang W, Yin S, Gu W, Zhang Y, Dong F, Wei J, Deng G, Xiang X, Zhou Y, Hou Y, Zhang Q, Xiong S, Liu J, Long L, Chen R, Chen J, Jiang X, Luo S, Chen Y, Jiang C, Zhao J, Ji L, Mei X, Li J, Li T, Zheng R, Zhou X, Ren H, Shi Y, Li H; Chinese (Acute on) Chronic Liver Failure Consortium (Ch-CLIF.C). Wang T, et al. JHEP Rep. 2022 Jul 5;4(10):100529. doi: 10.1016/j.jhepr.2022.100529. eCollection 2022 Oct. JHEP Rep. 2022. PMID: 36052222 Free PMC article.
BACKGROUND & AIMS: Pre-acute-on-chronic liver failure (ACLF) is a distinct intermediate stage between acute decompensation (AD) and ACLF. ...We also developed a precipitant-based model (i.e. a model that incorporated information about …
BACKGROUND & AIMS: Pre-acute-on-chronic liver failure (ACLF) is a distinct intermediate stage between …
Spontaneous Fungal Ascites Infection in Patients with Cirrhosis: An Analysis of 10 Cases.
Li B, Yang C, Qian Z, Huang Y, Wang X, Zhong G, Chen J. Li B, et al. Infect Dis Ther. 2021 Jun;10(2):1033-1043. doi: 10.1007/s40121-021-00422-w. Epub 2021 Mar 11. Infect Dis Ther. 2021. PMID: 33709385 Free PMC article.
Candida albicans was the most frequently isolated fungus isolated from the ascites fluid. Three of the ten patients fulfilled the criteria of acute-on-chronic liver failure (ACLF) at baseline, and three of the remaining seven patients developed ACLF du …
Candida albicans was the most frequently isolated fungus isolated from the ascites fluid. Three of the ten patients fulfilled the criteria o …
Clinical features and outcomes of bacterascites in cirrhotic patients: A retrospective, multicentre study.
Li B, Gao Y, Wang X, Qian Z, Meng Z, Huang Y, Deng G, Lu X, Liu F, Zheng X, Li H, Chen J. Li B, et al. Liver Int. 2020 Jun;40(6):1447-1456. doi: 10.1111/liv.14418. Epub 2020 Mar 17. Liver Int. 2020. PMID: 32128975

Gram-positive bacteria were more prevalent in bacterascites patients than in culture-positive SBP patients (59.1% vs 22.0%; P < .001). For patients with acute-on-chronic liver failure (ACLF) in bacterascites and culture-positive SBP groups, the 28-d

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Gram-positive bacteria were more prevalent in bacterascites patients than in culture-positive SBP patients (59.1% vs 22.0%; P < .001). Fo

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Alterations in the Gut Microbiota and Hepatitis-B-Virus Infection in Southern Chinese Patients With Coexisting Non-Alcoholic Fatty Liver Disease and Type-2 Diabetes Mellitus.
Han W, Huang C, Ji Y, Zhou L, Chen J, Hou J. Han W, et al. Front Med (Lausanne). 2021 Dec 21;8:805029. doi: 10.3389/fmed.2021.805029. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34993216 Free PMC article.
We aimed to elucidate the compositional and functional characteristics of the microbiota in southern Chinese patients with coexistent HBV infection, non-alcoholic fatty liver disease (NAFLD), and type-2 diabetes mellitus (T2DM). ...
We aimed to elucidate the compositional and functional characteristics of the microbiota in southern Chinese patients with coexistent …