Chin S - Search Results

1

Directed differentiation of cholangiocytes from human pluripotent stem cells.

Ogawa M, Ogawa S, Bear CE, Ahmadi S, Chin S, Li B, Grompe M, Keller G, Kamath BM, Ghanekar A. Ogawa M, et al. Among authors: chin s. Nat Biotechnol. 2015 Aug;33(8):853-61. doi: 10.1038/nbt.3294. Epub 2015 Jul 13. Nat Biotechnol. 2015. PMID: 26167630

2

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.

Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J. Wong AP, et al. Among authors: chin s. Nat Biotechnol. 2012 Sep;30(9):876-82. doi: 10.1038/nbt.2328. Nat Biotechnol. 2012. PMID: 22922672 Free PMC article.

3

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.

Wong AP, Chin S, Xia S, Garner J, Bear CE, Rossant J. Wong AP, et al. Among authors: chin s. Nat Protoc. 2015 Mar;10(3):363-81. doi: 10.1038/nprot.2015.021. Epub 2015 Feb 5. Nat Protoc. 2015. PMID: 25654755

4

Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans.

Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear CE, Post M. Shojaie S, et al. Among authors: chin s. Stem Cell Reports. 2015 Mar 10;4(3):419-30. doi: 10.1016/j.stemcr.2015.01.004. Epub 2015 Feb 5. Stem Cell Reports. 2015. PMID: 25660407 Free PMC article.

5

Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.

Chin S, Hung M, Bear CE. Chin S, et al. Cell Mol Life Sci. 2017 Jan;74(1):57-66. doi: 10.1007/s00018-016-2388-6. Epub 2016 Oct 8. Cell Mol Life Sci. 2017. PMID: 27722768 Review.

6

Functional Rescue of F508del-CFTR Using Small Molecule Correctors.

Molinski S, Eckford PD, Pasyk S, Ahmadi S, Chin S, Bear CE. Molinski S, et al. Among authors: chin s. Front Pharmacol. 2012 Sep 26;3:160. doi: 10.3389/fphar.2012.00160. eCollection 2012. Front Pharmacol. 2012. PMID: 23055971 Free PMC article.

7

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

Pasyk S, Molinski S, Ahmadi S, Ramjeesingh M, Huan LJ, Chin S, Du K, Yeger H, Taylor P, Moran MF, Bear CE. Pasyk S, et al. Among authors: chin s. Proteomics. 2015 Jan;15(2-3):447-61. doi: 10.1002/pmic.201400218. Epub 2014 Dec 17. Proteomics. 2015. PMID: 25330774

8

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.

Chin S, Yang D, Miles AJ, Eckford PDW, Molinski S, Wallace BA, Bear CE. Chin S, et al. J Biol Chem. 2017 Feb 3;292(5):1988-1999. doi: 10.1074/jbc.M116.762633. Epub 2016 Dec 21. J Biol Chem. 2017. PMID: 28003367 Free PMC article.

9

Structural effects of extracellular loop mutations in CFTR helical hairpins.

Chang YH, Stone TA, Chin S, Glibowicka M, Bear CE, Deber CM. Chang YH, et al. Among authors: chin s. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1092-1098. doi: 10.1016/j.bbamem.2018.01.003. Epub 2018 Jan 5. Biochim Biophys Acta Biomembr. 2018. PMID: 29307731 Free article.

10

Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del.

Chin S, Hung M, Won A, Wu YS, Ahmadi S, Yang D, Elmallah S, Toutah K, Hamilton CM, Young RN, Viirre RD, Yip CM, Bear CE. Chin S, et al. Mol Pharmacol. 2018 Aug;94(2):917-925. doi: 10.1124/mol.118.112177. Epub 2018 Jun 14. Mol Pharmacol. 2018. PMID: 29903751

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