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An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, Jeon JH, Park KG, Lee IK, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: chin j. Eur J Med Chem. 2020 Nov 1;205:112501. doi: 10.1016/j.ejmech.2020.112501. Epub 2020 Jul 14. Eur J Med Chem. 2020. PMID: 32758860
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
Kim J, Woo SY, Im CY, Yoo EK, Lee S, Kim HJ, Hwang HJ, Cho JH, Lee WS, Yoon H, Kim S, Kwon OB, Hwang H, Kim KH, Jeon JH, Singh TD, Kim SW, Hwang SY, Choi HS, Lee IK, Kim SH, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: chin j. J Med Chem. 2016 Nov 23;59(22):10209-10227. doi: 10.1021/acs.jmedchem.6b01204. Epub 2016 Nov 9. J Med Chem. 2016. PMID: 27805390
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
Kim J, Song J, Ji HD, Yoo EK, Lee JE, Lee SB, Oh JM, Lee S, Hwang JS, Yoon H, Kim DS, Lee SJ, Jeong M, Lee S, Kim KH, Choi HS, Lee SW, Park KG, Lee IK, Kim SH, Hwang H, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: chin j. J Med Chem. 2019 Feb 28;62(4):1837-1858. doi: 10.1021/acs.jmedchem.8b01296. Epub 2019 Feb 4. J Med Chem. 2019. PMID: 30657313
Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents.
Man Kadayat T, Eun Kim D, Bong Lee S, Jung K, Eun Park S, Hong JY, Kim J, Shrestha A, Kim DS, An H, Kim N, Lee SJ, Kwon S, Kim S, Yeon Hwang J, Kim S, Hahn D, Choi H, Nam SJ, Hyun Jeon Y, Jin Hwang J, Jin Cho S, Chin J. Man Kadayat T, et al. Among authors: chin j. Bioorg Chem. 2021 Aug;113:105027. doi: 10.1016/j.bioorg.2021.105027. Epub 2021 May 26. Bioorg Chem. 2021. PMID: 34098398
Identification of Selective ERRγ Inverse Agonists.
Kim J, Im CY, Yoo EK, Ma MJ, Kim SB, Hong E, Chin J, Hwang H, Lee S, Kim ND, Jeon JH, Lee IK, Jeon YH, Choi HS, Kim SH, Cho SJ. Kim J, et al. Among authors: chin j. Molecules. 2016 Jan 12;21(1):80. doi: 10.3390/molecules21010080. Molecules. 2016. PMID: 26771593 Free PMC article.
2,131 results