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Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport.
Chua GL, Tan BC, Loke RYJ, He M, Chin CF, Wong BH, Kuk ACY, Ding M, Wenk MR, Guan L, Torta F, Silver DL. Chua GL, et al. Among authors: chin cf. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2215290120. doi: 10.1073/pnas.2215290120. Epub 2023 Feb 27. Proc Natl Acad Sci U S A. 2023. PMID: 36848557 Free PMC article.
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.
Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S, Wenk MR, Cazenave-Gassiot A, Silver DL. Chan JP, et al. Among authors: chin cf. PLoS Biol. 2018 Aug 3;16(8):e2006443. doi: 10.1371/journal.pbio.2006443. eCollection 2018 Aug. PLoS Biol. 2018. PMID: 30074985 Free PMC article.
Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features.
Scala M, Chua GL, Chin CF, Alsaif HS, Borovikov A, Riazuddin S, Riazuddin S, Chiara Manzini M, Severino M, Kuk A, Fan H, Jamshidi Y, Toosi MB, Doosti M, Karimiani EG, Salpietro V, Dadali E, Baydakova G, Konovalov F, Lozier E, O'Connor E, Sabr Y, Alfaifi A, Ashrafzadeh F, Striano P, Zara F, Alkuraya FS, Houlden H, Maroofian R, Silver DL. Scala M, et al. Among authors: chin cf. Eur J Hum Genet. 2020 Nov;28(11):1509-1519. doi: 10.1038/s41431-020-0669-x. Epub 2020 Jun 22. Eur J Hum Genet. 2020. PMID: 32572202 Free PMC article.
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Cater RJ, Chua GL, Erramilli SK, Keener JE, Choy BC, Tokarz P, Chin CF, Quek DQY, Kloss B, Pepe JG, Parisi G, Wong BH, Clarke OB, Marty MT, Kossiakoff AA, Khelashvili G, Silver DL, Mancia F. Cater RJ, et al. Among authors: chin cf. Nature. 2021 Jul;595(7866):315-319. doi: 10.1038/s41586-021-03650-9. Epub 2021 Jun 16. Nature. 2021. PMID: 34135507 Free PMC article.
Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
He M, Kuk ACY, Ding M, Chin CF, Galam DLA, Nah JM, Tan BC, Yeo HL, Chua GL, Benke PI, Wenk MR, Ho L, Torta F, Silver DL. He M, et al. Among authors: chin cf. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210353119. doi: 10.1073/pnas.2210353119. Epub 2022 Sep 26. Proc Natl Acad Sci U S A. 2022. PMID: 36161949 Free PMC article.
Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.
Chichili VPR, Chew TW, Shankar S, Er SY, Chin CF, Jobichen C, Qiurong Pan C, Zhou Y, Yeong FM, Low BC, Sivaraman J. Chichili VPR, et al. Among authors: chin cf. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2014242118. doi: 10.1073/pnas.2014242118. Proc Natl Acad Sci U S A. 2021. PMID: 34006635 Free PMC article.
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