Childress ES - Search Results

1

Spatial asynchrony and cross-scale climate interactions in populations of a coldwater stream fish.

Valentine GP, Lu X, Childress ES, Dolloff CA, Hitt NP, Kulp MA, Letcher BH, Pregler KC, Rash JM, Hooten MB, Kanno Y. Valentine GP, et al. Among authors: childress es. Glob Chang Biol. 2024 Jan;30(1):e17029. doi: 10.1111/gcb.17029. Epub 2023 Nov 21. Glob Chang Biol. 2024. PMID: 37987546

2

Nematode development is inhibited by methyl viologen and high oxygen concentrations at a rate inversely proportional to life span.

Hartman P, Childress E, Beyer T. Hartman P, et al. J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B322-6. doi: 10.1093/gerona/50a.6.b322. J Gerontol A Biol Sci Med Sci. 1995. PMID: 7583787

3

Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.

Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Hargett SR, Childress ES, Salamoun JM, Aleksovska I, Roseblade A, Cranfield C, Rawling T, Quinlan KGR, Morris MJ, Tucker SP, Santos WL, Hoehn KL. Chen SY, et al. Among authors: childress es. Metabolism. 2021 Apr;117:154724. doi: 10.1016/j.metabol.2021.154724. Epub 2021 Feb 4. Metabolism. 2021. PMID: 33548253

4

[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.

Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.

5

Evaluation of Synthetic Cytochrome P₄₅₀-Mimetic Metalloporphyrins To Facilitate "Biomimetic" Biotransformation of a Series of mGlu₅ Allosteric Ligands.

Presley CC, Perry CK, Childress ES, Mulder MJ, Luscombe VB, Rodriguez AL, Niswender CM, Conn PJ, Lindsley CW. Presley CC, et al. Among authors: childress es. ACS Omega. 2019 Jul 26;4(7):12782-12789. doi: 10.1021/acsomega.9b02017. eCollection 2019 Jul 31. ACS Omega. 2019. PMID: 31460402 Free PMC article.

6

Total Synthesis of Hinduchelins A-D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues.

Childress ES, Garrison AT, Sheldon JR, Skaar EP, Lindsley CW. Childress ES, et al. J Org Chem. 2019 May 17;84(10):6459-6464. doi: 10.1021/acs.joc.9b00391. Epub 2019 May 8. J Org Chem. 2019. PMID: 31039303 Free PMC article.

7

Preparation of 1,5-Dihydropyrazolo[3',4':5,6]pyrano[3,4- b]pyridines via a Microwave-Assisted, Palladium-Catalyzed Regioselective C-H Heteroarylation of Electron-Rich Pyrazoles.

Garrison AT, Childress ES, Davis DC, Lindsley CW. Garrison AT, et al. Among authors: childress es. J Org Chem. 2019 May 3;84(9):5855-5862. doi: 10.1021/acs.joc.9b00144. Epub 2019 Mar 7. J Org Chem. 2019. PMID: 30807155

8

Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu₂) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores.

Childress ES, Wieting JM, Felts AS, Breiner MM, Long MF, Luscombe VB, Rodriguez AL, Cho HP, Blobaum AL, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW. Childress ES, et al. J Med Chem. 2019 Jan 10;62(1):378-384. doi: 10.1021/acs.jmedchem.8b01266. Epub 2018 Oct 31. J Med Chem. 2019. PMID: 30350962

9

VU6007477, a Novel M₁ PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events.

Engers JL, Childress ES, Long MF, Capstick RA, Luscombe VB, Cho HP, Dickerson JW, Rook JM, Blobaum AL, Niswender CM, Engers DW, Conn PJ, Lindsley CW. Engers JL, et al. Among authors: childress es. ACS Med Chem Lett. 2018 Sep 4;9(9):917-922. doi: 10.1021/acsmedchemlett.8b00261. eCollection 2018 Sep 13. ACS Med Chem Lett. 2018. PMID: 30258541 Free PMC article.

10

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential.

Childress ES, Alexopoulos SJ, Hoehn KL, Santos WL. Childress ES, et al. J Med Chem. 2018 Jun 14;61(11):4641-4655. doi: 10.1021/acs.jmedchem.7b01182. Epub 2017 Dec 8. J Med Chem. 2018. PMID: 29156129 Review.

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