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Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation.
Dumez ME, Teller N, Mercier F, Tanaka T, Vandenberghe I, Vandenbranden M, Devreese B, Luxen A, Frère JM, Matagne A, Jacquet A, Galleni M, Chevigné A. Dumez ME, et al. Among authors: chevigne a. J Biol Chem. 2008 Nov 7;283(45):30606-17. doi: 10.1074/jbc.M803041200. Epub 2008 Aug 25. J Biol Chem. 2008. PMID: 18725410 Free PMC article.
Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus.
Herman J, Thelen N, Smargiasso N, Mailleux AC, Luxen A, Cloes M, De Pauw E, Chevigné A, Galleni M, Dumez ME. Herman J, et al. Among authors: chevigne a. Biochim Biophys Acta. 2014 Mar;1840(3):1117-24. doi: 10.1016/j.bbagen.2013.11.017. Epub 2013 Nov 27. Biochim Biophys Acta. 2014. PMID: 24291687 Free article.
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