Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.
Doñate Puertas R, Meugnier E, Romestaing C, Rey C, Morel E, Lachuer J, Gadot N, Scridon A, Julien C, Tronc F, Chapuis B, Valla C, Janin A, Pirola L, Méjat A, Rome S, Chevalier P.
Doñate Puertas R, et al. Among authors: chevalier p.
Transl Res. 2017 Jun;184:57-67.e5. doi: 10.1016/j.trsl.2017.03.004. Epub 2017 Mar 30.
Transl Res. 2017.
PMID: 28427903