Cheung JR - Search Results

1

2-Hydroxypyridine-N-oxide (HOPO): Equivocal in the ames assay.

Dobo KL, Cheung JR, Gunther WC, Kenyon MO. Dobo KL, et al. Among authors: cheung jr. Environ Mol Mutagen. 2018 May;59(4):312-321. doi: 10.1002/em.22179. Epub 2018 Feb 26. Environ Mol Mutagen. 2018. PMID: 29481708

2

Resolution of contradiction between in silico predictions and Ames test results for four pharmaceutically relevant impurities.

Gunther WC, Kenyon MO, Cheung JR, Dugger RW, Dobo KL. Gunther WC, et al. Among authors: cheung jr. Regul Toxicol Pharmacol. 2017 Dec;91:68-76. doi: 10.1016/j.yrtph.2017.10.011. Epub 2017 Oct 20. Regul Toxicol Pharmacol. 2017. PMID: 29061373

3

An evaluation of the sensitivity of the Ames assay to discern low-level mutagenic impurities.

Kenyon MO, Cheung JR, Dobo KL, Ku WW. Kenyon MO, et al. Among authors: cheung jr. Regul Toxicol Pharmacol. 2007 Jun;48(1):75-86. doi: 10.1016/j.yrtph.2007.01.006. Epub 2007 Feb 4. Regul Toxicol Pharmacol. 2007. PMID: 17379368

4

A practical application of two in silico systems for identification of potentially mutagenic impurities.

Greene N, Dobo KL, Kenyon MO, Cheung J, Munzner J, Sobol Z, Sluggett G, Zelesky T, Sutter A, Wichard J. Greene N, et al. Regul Toxicol Pharmacol. 2015 Jul;72(2):335-49. doi: 10.1016/j.yrtph.2015.05.008. Epub 2015 May 15. Regul Toxicol Pharmacol. 2015. PMID: 25980641

5

Development and validation of an in vitro micronucleus assay platform in TK6 cells.

Sobol Z, Homiski ML, Dickinson DA, Spellman RA, Li D, Scott A, Cheung JR, Coffing SL, Munzner JB, Sanok KE, Gunther WC, Dobo KL, Schuler M. Sobol Z, et al. Among authors: cheung jr. Mutat Res. 2012 Jul 4;746(1):29-34. doi: 10.1016/j.mrgentox.2012.02.005. Epub 2012 Mar 13. Mutat Res. 2012. PMID: 22445949

6

Bioluminescent Salmonella reverse mutation assay: a screen for detecting mutagenicity with high throughput attributes.

Aubrecht J, Osowski JJ, Persaud P, Cheung JR, Ackerman J, Lopes SH, Ku WW. Aubrecht J, et al. Among authors: cheung jr. Mutagenesis. 2007 Sep;22(5):335-42. doi: 10.1093/mutage/gem022. Epub 2007 Jul 26. Mutagenesis. 2007. PMID: 17656636

7

Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.

Cheung JR, Dickinson DA, Moss J, Schuler MJ, Spellman RA, Heard PL. Cheung JR, et al. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jan 1;777:7-16. doi: 10.1016/j.mrgentox.2014.11.002. Epub 2014 Nov 15. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 25726170

8

Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines.

Trejo-Martin A, Bercu JP, Thresher A, Tennant RE, Thomas RF, Cross K, Czich A, Waese K, Nicolette JJ, Murray J, Sonders P, Kondratiuk A, Cheung JR, Thomas D, Lynch A, Harvey J, Glowienke S, Custer L, Escobar PA. Trejo-Martin A, et al. Among authors: cheung jr. Regul Toxicol Pharmacol. 2022 Nov;135:105247. doi: 10.1016/j.yrtph.2022.105247. Epub 2022 Aug 23. Regul Toxicol Pharmacol. 2022. PMID: 35998738 Free article.

9

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K. Kalgutkar AS, et al. Among authors: cheung jr. Drug Metab Dispos. 2007 Jun;35(6):848-58. doi: 10.1124/dmd.106.013649. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344339

10

Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M^pro inhibitor in animal models.

Catlin NR, Bowman CJ, Campion SN, Cheung JR, Nowland WS, Sathish JG, Stethem CM, Updyke L, Cappon GD. Catlin NR, et al. Among authors: cheung jr. Reprod Toxicol. 2022 Mar;108:56-61. doi: 10.1016/j.reprotox.2022.01.006. Epub 2022 Jan 31. Reprod Toxicol. 2022. PMID: 35101563 Free PMC article.

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