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The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Chernyshova IA, Zakharenko AL, Kurochkin NN, Dyrkheeva NS, Kornienko TE, Popova NA, Nikolin VP, Ilina ES, Zharkov TD, Kupryushkin MS, Oslovsky VE, Drenichev MS, Lavrik OI. Chernyshova IA, et al. Molecules. 2022 Dec 31;28(1):323. doi: 10.3390/molecules28010323. Molecules. 2022. PMID: 36615517 Free PMC article.
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Dyrkheeva NS, Filimonov AS, Luzina OA, Orlova KA, Chernyshova IA, Kornienko TE, Malakhova AA, Medvedev SP, Zakharenko AL, Ilina ES, Anarbaev RO, Naumenko KN, Klabenkova KV, Burakova EA, Stetsenko DA, Zakian SM, Salakhutdinov NF, Lavrik OI. Dyrkheeva NS, et al. Among authors: chernyshova ia. Int J Mol Sci. 2021 Oct 20;22(21):11336. doi: 10.3390/ijms222111336. Int J Mol Sci. 2021. PMID: 34768766 Free PMC article.
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Dyrkheeva NS, Chernyshova IA, Ivanov GA, Porozov YB, Zenchenko AA, Oslovsky VE, Zakharenko AL, Nasyrova DI, Likhatskaya GN, Mikhailov SN, Lavrik OI, Drenichev MS. Dyrkheeva NS, et al. Among authors: chernyshova ia. Molecules. 2022 Apr 9;27(8):2433. doi: 10.3390/molecules27082433. Molecules. 2022. PMID: 35458631 Free PMC article.
Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan.
Chepanova AA, Zakharenko AL, Dyrkheeva NS, Chernyshova IA, Zakharova OD, Ilina ES, Luzina OA, Salakhutdinov NF, Lavrik OI. Chepanova AA, et al. Among authors: chernyshova ia. Dokl Biochem Biophys. 2023 Feb;508(1):25-30. doi: 10.1134/S1607672922700077. Epub 2023 Jan 18. Dokl Biochem Biophys. 2023. PMID: 36653585 Free PMC article.
Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties.
Kovaleva K, Yarovaya O, Ponomarev K, Cheresiz S, Azimirad A, Chernyshova I, Zakharenko A, Konev V, Khlebnikova T, Mozhaytsev E, Suslov E, Nilov D, Švedas V, Pokrovsky A, Lavrik O, Salakhutdinov N. Kovaleva K, et al. Pharmaceuticals (Basel). 2021 May 1;14(5):422. doi: 10.3390/ph14050422. Pharmaceuticals (Basel). 2021. PMID: 34062881 Free PMC article.