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Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.
Martín Sánchez C, Pérez Martín JM, Jin JS, Dávalos A, Zhang W, de la Peña G, Martínez-Botas J, Rodríguez-Acebes S, Suárez Y, Hazen MJ, Gómez-Coronado D, Busto R, Cheng YC, Lasunción MA. Martín Sánchez C, et al. Among authors: cheng yc. Biochim Biophys Acta. 2015 Sep;1851(9):1240-53. doi: 10.1016/j.bbalip.2015.06.001. Epub 2015 Jun 5. Biochim Biophys Acta. 2015. PMID: 26055626
Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
Zhang W, Saif MW, Dutschman GE, Li X, Lam W, Bussom S, Jiang Z, Ye M, Chu E, Cheng YC. Zhang W, et al. Among authors: cheng yc. J Chromatogr A. 2010 Sep 10;1217(37):5785-93. doi: 10.1016/j.chroma.2010.07.045. Epub 2010 Jul 21. J Chromatogr A. 2010. PMID: 20696432 Free PMC article.
TREX1 acts in degrading damaged DNA from drug-treated tumor cells.
Wang CJ, Lam W, Bussom S, Chang HM, Cheng YC. Wang CJ, et al. Among authors: cheng yc. DNA Repair (Amst). 2009 Oct 2;8(10):1179-89. doi: 10.1016/j.dnarep.2009.06.006. Epub 2009 Jul 18. DNA Repair (Amst). 2009. PMID: 19617005 Free PMC article.
1,488 results