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Fabs enable single particle cryoEM studies of small proteins.
Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Wu S, et al. Among authors: cheng y. Structure. 2012 Apr 4;20(4):582-92. doi: 10.1016/j.str.2012.02.017. Epub 2012 Apr 3. Structure. 2012. PMID: 22483106 Free PMC article.
Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY. Dang S, et al. Among authors: cheng y. Nature. 2017 Dec 21;552(7685):426-429. doi: 10.1038/nature25024. Epub 2017 Dec 13. Nature. 2017. PMID: 29236684 Free PMC article.
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. Binning JM, et al. Among authors: cheng y. PLoS Pathog. 2018 Jan 5;14(1):e1006830. doi: 10.1371/journal.ppat.1006830. eCollection 2018 Jan. PLoS Pathog. 2018. PMID: 29304101 Free PMC article.
Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Kintzer AF, et al. Among authors: cheng y. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9095-E9104. doi: 10.1073/pnas.1805651115. Epub 2018 Sep 6. Proc Natl Acad Sci U S A. 2018. PMID: 30190435 Free PMC article.
Why recombinant antibodies - benefits and applications.
Basu K, Green EM, Cheng Y, Craik CS. Basu K, et al. Among authors: cheng y. Curr Opin Biotechnol. 2019 Dec;60:153-158. doi: 10.1016/j.copbio.2019.01.012. Epub 2019 Mar 5. Curr Opin Biotechnol. 2019. PMID: 30849700 Free PMC article. Review.
Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly E, Young NJ, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. Asarnow D, et al. Among authors: cheng y. Cell. 2021 Jun 10;184(12):3192-3204.e16. doi: 10.1016/j.cell.2021.04.033. Epub 2021 Apr 24. Cell. 2021. PMID: 33974910 Free PMC article.
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