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GPCR activation and GRK2 assembly by a biased intracellular agonist.
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE. Duan J, et al. Among authors: cheng x. Nature. 2023 Aug;620(7974):676-681. doi: 10.1038/s41586-023-06395-9. Epub 2023 Aug 2. Nature. 2023. PMID: 37532940
Structural basis for activation of the growth hormone-releasing hormone receptor.
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW. Zhou F, et al. Among authors: cheng x. Nat Commun. 2020 Oct 15;11(1):5205. doi: 10.1038/s41467-020-18945-0. Nat Commun. 2020. PMID: 33060564 Free PMC article.
Structures of the human dopamine D3 receptor-Gi complexes.
Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE. Xu P, et al. Among authors: cheng x. Mol Cell. 2021 Mar 18;81(6):1147-1159.e4. doi: 10.1016/j.molcel.2021.01.003. Epub 2021 Feb 5. Mol Cell. 2021. PMID: 33548201 Free article.
Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE. Zhuang Y, et al. Among authors: cheng x. Cell. 2021 Feb 18;184(4):931-942.e18. doi: 10.1016/j.cell.2021.01.027. Epub 2021 Feb 10. Cell. 2021. PMID: 33571431 Free PMC article.
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE. Zhuang Y, et al. Among authors: cheng x. Cell Res. 2021 May;31(5):593-596. doi: 10.1038/s41422-021-00482-0. Epub 2021 Mar 9. Cell Res. 2021. PMID: 33750903 Free PMC article. No abstract available.
Structural insights into the lipid and ligand regulation of serotonin receptors.
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsøe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE. Xu P, et al. Among authors: cheng x. Nature. 2021 Apr;592(7854):469-473. doi: 10.1038/s41586-021-03376-8. Epub 2021 Mar 24. Nature. 2021. PMID: 33762731
Structures of full-length glycoprotein hormone receptor signalling complexes.
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE. Duan J, et al. Among authors: cheng x. Nature. 2021 Oct;598(7882):688-692. doi: 10.1038/s41586-021-03924-2. Epub 2021 Sep 22. Nature. 2021. PMID: 34552239
Constitutive signal bias mediated by the human GHRHR splice variant 1.
Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW. Cong Z, et al. Among authors: cheng x. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2106606118. doi: 10.1073/pnas.2106606118. Proc Natl Acad Sci U S A. 2021. PMID: 34599099 Free PMC article.
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