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High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors.
Zang Y, Su M, Wang Q, Cheng X, Zhang W, Zhao Y, Chen T, Jiang Y, Shen Q, Du J, Tan Q, Wang P, Gao L, Jin Z, Zhang M, Li C, Zhu Y, Feng B, Tang B, Xie H, Wang MW, Zheng M, Pan X, Yang H, Xu Y, Wu B, Zhang L, Rao Z, Yang X, Jiang H, Xiao G, Zhao Q, Li J. Zang Y, et al. Among authors: cheng x. Protein Cell. 2022 Sep 28;14(1):17-27. doi: 10.1093/procel/pwac016. eCollection 2023 Jan. Protein Cell. 2022. PMID: 36726755 Free PMC article.
Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Zhang B, Li J, Yang X, Wu L, Zhang J, Yang Y, Zhao Y, Zhang L, Yang X, Yang X, Cheng X, Liu Z, Jiang B, Jiang H, Guddat LW, Yang H, Rao Z. Zhang B, et al. Among authors: cheng x. Cell. 2019 Jan 24;176(3):636-648.e13. doi: 10.1016/j.cell.2019.01.003. Cell. 2019. PMID: 30682372 Free article.
Allostery in Drug Development.
Cheng X, Jiang H. Cheng X, et al. Adv Exp Med Biol. 2019;1163:1-23. doi: 10.1007/978-981-13-8719-7_1. Adv Exp Med Biol. 2019. PMID: 31707697 Review.
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, Xie X, Jin Z, Peng J, Liu F, Li C, Li Y, Bai F, Wang H, Cheng X, Cen X, Hu S, Yang X, Wang J, Liu X, Xiao G, Jiang H, Rao Z, Zhang LK, Xu Y, Yang H, Liu H. Dai W, et al. Among authors: cheng x. Science. 2020 Jun 19;368(6497):1331-1335. doi: 10.1126/science.abb4489. Epub 2020 Apr 22. Science. 2020. PMID: 32321856 Free PMC article.
Structural basis for activation of the growth hormone-releasing hormone receptor.
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW. Zhou F, et al. Among authors: cheng x. Nat Commun. 2020 Oct 15;11(1):5205. doi: 10.1038/s41467-020-18945-0. Nat Commun. 2020. PMID: 33060564 Free PMC article.
Structures of the human dopamine D3 receptor-Gi complexes.
Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE. Xu P, et al. Among authors: cheng x. Mol Cell. 2021 Mar 18;81(6):1147-1159.e4. doi: 10.1016/j.molcel.2021.01.003. Epub 2021 Feb 5. Mol Cell. 2021. PMID: 33548201 Free article.
Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE. Zhuang Y, et al. Among authors: cheng x. Cell. 2021 Feb 18;184(4):931-942.e18. doi: 10.1016/j.cell.2021.01.027. Epub 2021 Feb 10. Cell. 2021. PMID: 33571431 Free PMC article.
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE. Zhuang Y, et al. Among authors: cheng x. Cell Res. 2021 May;31(5):593-596. doi: 10.1038/s41422-021-00482-0. Epub 2021 Mar 9. Cell Res. 2021. PMID: 33750903 Free PMC article. No abstract available.
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.
Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z. Xia B, et al. Among authors: cheng x. Cell Res. 2021 Aug;31(8):847-860. doi: 10.1038/s41422-021-00519-4. Epub 2021 Jun 10. Cell Res. 2021. PMID: 34112954 Free PMC article.
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates.
Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ. Wang Y, et al. Among authors: cheng x. Acta Pharmacol Sin. 2022 Apr;43(4):781-787. doi: 10.1038/s41401-021-00732-2. Epub 2021 Jul 22. Acta Pharmacol Sin. 2022. PMID: 34294887 Free PMC article.
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