Cheng J - Search Results

1

5-HT_2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.

Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC. Pogorelov VM, et al. Among authors: cheng j. Neuropsychopharmacology. 2017 Oct;42(11):2163-2177. doi: 10.1038/npp.2017.52. Epub 2017 Mar 15. Neuropsychopharmacology. 2017. PMID: 28294132 Free PMC article.

2

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25633969 Free PMC article.

3

Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist.

Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Cheng J, et al. Tetrahedron Lett. 2015 Jun 3;56(23):3420-3422. doi: 10.1016/j.tetlet.2015.01.060. Tetrahedron Lett. 2015. PMID: 26120215 Free PMC article.

4

We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders.

Cheng J, Kozikowski AP. Cheng J, et al. ChemMedChem. 2015 Dec;10(12):1963-7. doi: 10.1002/cmdc.201500437. Epub 2015 Oct 28. ChemMedChem. 2015. PMID: 26507582 Free PMC article.

5

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.

Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Jan 28;59(2):578-91. doi: 10.1021/acs.jmedchem.5b01153. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26704965 Free PMC article.

6

Design and Discovery of Functionally Selective Serotonin 2C (5-HT_2C) Receptor Agonists.

Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Nov 10;59(21):9866-9880. doi: 10.1021/acs.jmedchem.6b01194. Epub 2016 Oct 25. J Med Chem. 2016. PMID: 27726356

7

Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.

Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Zhang G, et al. Among authors: cheng j. J Med Chem. 2017 Jul 27;60(14):6273-6288. doi: 10.1021/acs.jmedchem.7b00584. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28657744 Free PMC article.

8

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ. Peng Y, et al. Among authors: cheng j. Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1. Cell. 2018. PMID: 29398112 Free PMC article.

9

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT_2C) receptor agonist without 5-HT_2B agonism.

Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Zhang G, et al. Among authors: cheng j. Eur J Med Chem. 2019 Nov 15;182:111626. doi: 10.1016/j.ejmech.2019.111626. Epub 2019 Aug 14. Eur J Med Chem. 2019. PMID: 31445232 Free PMC article.

10

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

Tan L, Zhou Q, Yan W, Sun J, Kozikowski AP, Zhao S, Huang XP, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2020 May 14;63(9):4579-4602. doi: 10.1021/acs.jmedchem.9b01835. Epub 2020 Apr 23. J Med Chem. 2020. PMID: 32282200

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