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Model Systems to Study the Mechanism of Vascular Aging.
van der Linden J, Trap L, Scherer CV, Roks AJM, Danser AHJ, van der Pluijm I, Cheng C. van der Linden J, et al. Among authors: cheng c. Int J Mol Sci. 2023 Oct 19;24(20):15379. doi: 10.3390/ijms242015379. Int J Mol Sci. 2023. PMID: 37895059 Free PMC article. Review.
Nucleotide excision DNA repair is associated with age-related vascular dysfunction.
Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Durik M, et al. Among authors: cheng c. Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15. Circulation. 2012. PMID: 22705887 Free PMC article.
Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening.
Sorop O, Heinonen I, van Kranenburg M, van de Wouw J, de Beer VJ, Nguyen ITN, Octavia Y, van Duin RWB, Stam K, van Geuns RJ, Wielopolski PA, Krestin GP, van den Meiracker AH, Verjans R, van Bilsen M, Danser AHJ, Paulus WJ, Cheng C, Linke WA, Joles JA, Verhaar MC, van der Velden J, Merkus D, Duncker DJ. Sorop O, et al. Among authors: cheng c. Cardiovasc Res. 2018 Jun 1;114(7):954-964. doi: 10.1093/cvr/cvy038. Cardiovasc Res. 2018. PMID: 29432575 Free PMC article.
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.
Krebber MM, van Dijk CGM, Vernooij RWM, Brandt MM, Emter CA, Rau CD, Fledderus JO, Duncker DJ, Verhaar MC, Cheng C, Joles JA. Krebber MM, et al. Among authors: cheng c. Int J Mol Sci. 2020 Sep 14;21(18):6742. doi: 10.3390/ijms21186742. Int J Mol Sci. 2020. PMID: 32937927 Free PMC article.
Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.
van der Linden J, Stefens SJM, Heredia-Genestar JM, Ridwan Y, Brandt RMC, van Vliet N, de Beer I, van Thiel BS, Steen H, Cheng C, Roks AJM, Danser AHJ, Essers J, van der Pluijm I. van der Linden J, et al. Among authors: cheng c. Aging Cell. 2024 Mar 7:e14126. doi: 10.1111/acel.14126. Online ahead of print. Aging Cell. 2024. PMID: 38451018 Free article.
The complex mural cell: pericyte function in health and disease.
van Dijk CG, Nieuweboer FE, Pei JY, Xu YJ, Burgisser P, van Mulligen E, el Azzouzi H, Duncker DJ, Verhaar MC, Cheng C. van Dijk CG, et al. Among authors: cheng c. Int J Cardiol. 2015;190:75-89. doi: 10.1016/j.ijcard.2015.03.258. Epub 2015 Mar 20. Int J Cardiol. 2015. PMID: 25918055 Review.
A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix.
van Dijk CGM, Brandt MM, Poulis N, Anten J, van der Moolen M, Kramer L, Homburg EFGA, Louzao-Martinez L, Pei J, Krebber MM, van Balkom BWM, de Graaf P, Duncker DJ, Verhaar MC, Luttge R, Cheng C. van Dijk CGM, et al. Among authors: cheng c. Lab Chip. 2020 May 19;20(10):1827-1844. doi: 10.1039/d0lc00059k. Lab Chip. 2020. PMID: 32330215
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