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The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid.
Varela Chavez C, Hoos S, Haustant GM, Chenal A, England P, Blondel A, Pauillac S, Lacy DB, Popoff MR. Varela Chavez C, et al. Among authors: chenal a. Cell Microbiol. 2015 Oct;17(10):1477-93. doi: 10.1111/cmi.12449. Epub 2015 May 13. Cell Microbiol. 2015. PMID: 25882477
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
O'Brien DP, Perez ACS, Karst J, Cannella SE, Enguéné VYN, Hessel A, Raoux-Barbot D, Voegele A, Subrini O, Davi M, Guijarro JI, Raynal B, Baron B, England P, Hernandez B, Ghomi M, Hourdel V, Malosse C, Chamot-Rooke J, Vachette P, Durand D, Brier S, Ladant D, Chenal A. O'Brien DP, et al. Among authors: chenal a. Toxicon. 2018 Jul;149:37-44. doi: 10.1016/j.toxicon.2018.01.007. Epub 2018 Jan 12. Toxicon. 2018. PMID: 29337218 Review.
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