Chen ZJ - Search Results

1

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.

Li T, Chen ZJ. Li T, et al. Among authors: chen zj. J Exp Med. 2018 May 7;215(5):1287-1299. doi: 10.1084/jem.20180139. Epub 2018 Apr 5. J Exp Med. 2018. PMID: 29622565 Free PMC article. Review.

2

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Sun L, Wu J, Du F, Chen X, Chen ZJ. Sun L, et al. Among authors: chen zj, chen x. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20. Science. 2013. PMID: 23258413 Free PMC article.

3

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. Zhang X, et al. Among authors: chen zj, chen c. Mol Cell. 2013 Jul 25;51(2):226-35. doi: 10.1016/j.molcel.2013.05.022. Epub 2013 Jun 6. Mol Cell. 2013. PMID: 23747010 Free PMC article.

4

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.

Li XD, Wu J, Gao D, Wang H, Sun L, Chen ZJ. Li XD, et al. Among authors: chen zj. Science. 2013 Sep 20;341(6152):1390-4. doi: 10.1126/science.1244040. Epub 2013 Aug 29. Science. 2013. PMID: 23989956 Free PMC article.

5

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.

Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. Zhang X, et al. Among authors: chen z, chen zj. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014 Jan 23. Cell Rep. 2014. PMID: 24462292 Free PMC article.

6

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.

Cai X, Chiu YH, Chen ZJ. Cai X, et al. Among authors: chen zj. Mol Cell. 2014 Apr 24;54(2):289-96. doi: 10.1016/j.molcel.2014.03.040. Mol Cell. 2014. PMID: 24766893 Free article. Review.

7

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR. Deng L, et al. Among authors: chen zj. Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6. Immunity. 2014. PMID: 25517616 Free PMC article.

8

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.

Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Karlsson Hedestam GB, Chen ZJ, Beutler B. Zeng M, et al. Among authors: chen zj. Science. 2014 Dec 19;346(6216):1486-92. doi: 10.1126/science.346.6216.1486. Science. 2014. PMID: 25525240 Free PMC article. Retracted.

9

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Among authors: chen zj. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.

10

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ. Liu S, et al. Among authors: chen zj, chen x. Science. 2015 Mar 13;347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29. Science. 2015. PMID: 25636800

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