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TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
Erazo T, Evans CM, Zakheim D, Chu KL, Refermat AY, Asgari Z, Yang X, Da Silva Ferreira M, Mehta S, Russo MV, Knezevic A, Zhang XP, Chen Z, Fennell M, Garippa R, Seshan V, de Stanchina E, Barbash O, Batlevi CL, Leslie CS, Melnick AM, Younes A, Kharas MG. Erazo T, et al. Among authors: chen z. Nat Commun. 2022 Sep 27;13(1):5676. doi: 10.1038/s41467-022-33137-8. Nat Commun. 2022. PMID: 36167829 Free PMC article.
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, Cantley LC, Green MR, Lin H, Melnick AM. Li M, et al. Among authors: chen z. Cancer Cell. 2019 Jun 10;35(6):916-931.e9. doi: 10.1016/j.ccell.2019.05.002. Cancer Cell. 2019. PMID: 31185214 Free PMC article.
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.
Kawabata KC, Zong H, Meydan C, Wyman S, Wouters BJ, Sugita M, Goswami S, Albert M, Yip W, Roboz GJ, Chen Z, Delwel R, Carroll M, Mason CE, Melnick A, Guzman ML. Kawabata KC, et al. Among authors: chen z. Blood. 2021 Feb 11;137(6):812-825. doi: 10.1182/blood.2019001745. Blood. 2021. PMID: 32911532 Free PMC article.
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Rivas MA, Meydan C, Chin CR, Challman MF, Kim D, Bhinder B, Kloetgen A, Viny AD, Teater MR, McNally DR, Doane AS, Béguelin W, Fernández MTC, Shen H, Wang X, Levine RL, Chen Z, Tsirigos A, Elemento O, Mason CE, Melnick AM. Rivas MA, et al. Among authors: chen z. Nat Immunol. 2021 Feb;22(2):240-253. doi: 10.1038/s41590-020-00827-8. Epub 2021 Jan 11. Nat Immunol. 2021. PMID: 33432228 Free PMC article.
BTG1 mutation yields supercompetitive B cells primed for malignant transformation.
Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A. Mlynarczyk C, et al. Among authors: chen z. Science. 2023 Jan 20;379(6629):eabj7412. doi: 10.1126/science.abj7412. Epub 2023 Jan 20. Science. 2023. PMID: 36656933 Free PMC article.
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