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Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling.
Sun X, Zhang B, Pan X, Huang H, Xie Z, Ma Y, Hu B, Wang J, Chen Z, Shi P. Sun X, et al. Among authors: chen z. FASEB J. 2019 Nov;33(11):12929-12940. doi: 10.1096/fj.201900887RR. Epub 2019 Sep 6. FASEB J. 2019. PMID: 31490085 Free PMC article.
In summary, OI, an itaconate derivative, can inhibit osteoclastogenesis in vitro and in vivo, indicating that OI could be a potential drug to treat osteoclast-related diseases; our results also link itaconate to the development of osteoporosis.-Sun, X., Zhang, B., Pan, X., Huang, …
In summary, OI, an itaconate derivative, can inhibit osteoclastogenesis in vitro and in vivo, indicating that OI could be a potential drug t …
USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ.
Yuan P, Feng Z, Huang H, Wang G, Chen Z, Xu G, Xie Z, Jie Z, Zhao X, Ma Q, Wang S, Shen Y, Huang Y, Han Y, Ye H, Wang J, Shi P, Sun X. Yuan P, et al. Among authors: chen z. Int J Biol Sci. 2022 May 1;18(8):3122-3136. doi: 10.7150/ijbs.65428. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637948 Free PMC article.
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