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Shear stress, SIRT1, and vascular homeostasis.
Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. Chen Z, et al. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10268-73. doi: 10.1073/pnas.1003833107. Epub 2010 May 17. Proc Natl Acad Sci U S A. 2010. PMID: 20479254 Free PMC article.
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.
Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau GY, Huang HD, Hsiao M, Shyy JY. Chen Z, et al. J Clin Invest. 2013 Mar;123(3):1057-67. doi: 10.1172/JCI65344. Epub 2013 Feb 15. J Clin Invest. 2013. PMID: 23426184 Free PMC article.
Shear stress activation of nuclear receptor PXR in endothelial detoxification.
Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N. Wang X, et al. Among authors: chen z. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13174-9. doi: 10.1073/pnas.1312065110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878263 Free PMC article.
Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a.
Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. Chen Z, et al. Among authors: chen jw. Circulation. 2015 Mar 3;131(9):805-14. doi: 10.1161/CIRCULATIONAHA.114.013675. Epub 2014 Dec 30. Circulation. 2015. PMID: 25550450 Free PMC article.
TIFA as a crucial mediator for NLRP3 inflammasome.
Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY. Lin TY, et al. Among authors: chen z. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15078-15083. doi: 10.1073/pnas.1618773114. Epub 2016 Dec 13. Proc Natl Acad Sci U S A. 2016. PMID: 27965388 Free PMC article.
MicroRNA-92a Mediates Endothelial Dysfunction in CKD.
Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY. Shang F, et al. Among authors: chen z. J Am Soc Nephrol. 2017 Nov;28(11):3251-3261. doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10. J Am Soc Nephrol. 2017. PMID: 28696247 Free PMC article.
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