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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Moquin SA, Simon O, Karuna R, Lakshminarayana SB, Yokokawa F, Wang F, Saravanan C, Zhang J, Day CW, Chan K, Wang QY, Lu S, Dong H, Wan KF, Lim SP, Liu W, Seh CC, Chen YL, Xu H, Barkan DT, Kounde CS, Sim WLS, Wang G, Yeo HQ, Zou B, Chan WL, Ding M, Song JG, Li M, Osborne C, Blasco F, Sarko C, Beer D, Bonamy GMC, Sasseville VG, Shi PY, Diagana TT, Yeung BKS, Gu F. Moquin SA, et al. Among authors: chen yl. Sci Transl Med. 2021 Feb 3;13(579):eabb2181. doi: 10.1126/scitranslmed.abb2181. Sci Transl Med. 2021. PMID: 33536278
Finding new medicines for flaviviral targets.
Keller TH, Chen YL, Knox JE, Lim SP, Ma NL, Patel SJ, Sampath A, Wang QY, Yin Z, Vasudevan SG. Keller TH, et al. Among authors: chen yl. Novartis Found Symp. 2006;277:102-14; discussion 114-9, 251-3. Novartis Found Symp. 2006. PMID: 17319157 Review.
Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic.
Ong SH, Yip JT, Chen YL, Liu W, Harun S, Lystiyaningsih E, Heriyanto B, Beckett CG, Mitchell WP, Hibberd ML, Suwandono A, Vasudevan SG, Schreiber MJ. Ong SH, et al. Among authors: chen yl. Infect Genet Evol. 2008 Mar;8(2):191-204. doi: 10.1016/j.meegid.2007.12.005. Epub 2007 Dec 25. Infect Genet Evol. 2008. PMID: 18243816
An adenosine nucleoside inhibitor of dengue virus.
Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, Kondreddi RR, Niyomrattanakit P, Lakshminarayana SB, Goh A, Xu HY, Liu W, Liu B, Lim JY, Ng CY, Qing M, Lim CC, Yip A, Wang G, Chan WL, Tan HP, Lin K, Zhang B, Zou G, Bernard KA, Garrett C, Beltz K, Dong M, Weaver M, He H, Pichota A, Dartois V, Keller TH, Shi PY. Yin Z, et al. Among authors: chen yl. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. doi: 10.1073/pnas.0907010106. Epub 2009 Nov 16. Proc Natl Acad Sci U S A. 2009. PMID: 19918064 Free PMC article.
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH. Yin Z, et al. Among authors: chen yl. J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z. J Med Chem. 2009. PMID: 20014868
Strategies for development of Dengue virus inhibitors.
Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, Shi PY. Noble CG, et al. Among authors: chen yl. Antiviral Res. 2010 Mar;85(3):450-62. doi: 10.1016/j.antiviral.2009.12.011. Epub 2010 Jan 8. Antiviral Res. 2010. PMID: 20060421 Review.
Inhibition of dengue virus polymerase by blocking of the RNA tunnel.
Niyomrattanakit P, Chen YL, Dong H, Yin Z, Qing M, Glickman JF, Lin K, Mueller D, Voshol H, Lim JY, Nilar S, Keller TH, Shi PY. Niyomrattanakit P, et al. Among authors: chen yl. J Virol. 2010 Jun;84(11):5678-86. doi: 10.1128/JVI.02451-09. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237086 Free PMC article.
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
Chen YL, Yin Z, Duraiswamy J, Schul W, Lim CC, Liu B, Xu HY, Qing M, Yip A, Wang G, Chan WL, Tan HP, Lo M, Liung S, Kondreddi RR, Rao R, Gu H, He H, Keller TH, Shi PY. Chen YL, et al. Antimicrob Agents Chemother. 2010 Jul;54(7):2932-9. doi: 10.1128/AAC.00140-10. Epub 2010 May 10. Antimicrob Agents Chemother. 2010. PMID: 20457821 Free PMC article.
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
Chen YL, Yin Z, Lakshminarayana SB, Qing M, Schul W, Duraiswamy J, Kondreddi RR, Goh A, Xu HY, Yip A, Liu B, Weaver M, Dartois V, Keller TH, Shi PY. Chen YL, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3255-61. doi: 10.1128/AAC.00397-10. Epub 2010 Jun 1. Antimicrob Agents Chemother. 2010. PMID: 20516277 Free PMC article.
4,259 results