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The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
Chang C, Rajasekaran M, Qiao Y, Dong H, Wang Y, Xia H, Deivasigamani A, Wu M, Sekar K, Gao H, Sun M, Niu Y, Li Q, Tao L, Yan Z, Wang M, Chen S, Zhao S, Chen D, Li L, Yang F, Gao H, Chen B, Su L, Xu L, Chen Y, Seshachalam VP, Chen G, Gunaratne J, Hong W, Shi J, Chen G, Grierson DS, Chabot B, Xie T, Hui KM, Chen J. Chang C, et al. Among authors: chen j, chen b, chen s, chen d, chen g, chen y. Nat Commun. 2022 Mar 16;13(1):1363. doi: 10.1038/s41467-022-29016-x. Nat Commun. 2022. PMID: 35296659 Free PMC article.
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma.
Chen Y, Xu L, Mayakonda A, Huang ML, Kanojia D, Tan TZ, Dakle P, Lin RY, Ke XY, Said JW, Chen J, Gery S, Ding LW, Jiang YY, Pang A, Puhaindran ME, Goh BC, Koeffler HP. Chen Y, et al. Among authors: chen j. Nat Commun. 2019 Mar 22;10(1):1353. doi: 10.1038/s41467-019-09257-z. Nat Commun. 2019. PMID: 30903020 Free PMC article.
Core transcriptional regulatory circuitries in cancer.
Chen Y, Xu L, Lin RY, Müschen M, Koeffler HP. Chen Y, et al. Oncogene. 2020 Oct;39(43):6633-6646. doi: 10.1038/s41388-020-01459-w. Epub 2020 Sep 17. Oncogene. 2020. PMID: 32943730 Free PMC article. Review.
Topography of transcriptionally active chromatin in glioblastoma.
Xu L, Chen Y, Huang Y, Sandanaraj E, Yu JS, Lin RY, Dakle P, Ke XY, Chong YK, Koh L, Mayakonda A, Nacro K, Hill J, Huang ML, Gery S, Lim SW, Huang Z, Xu Y, Chen J, Bai L, Wang S, Wakimoto H, Yeo TT, Ang BT, Müschen M, Tang C, Tan TZ, Koeffler HP. Xu L, et al. Among authors: chen j, chen y. Sci Adv. 2021 Apr 30;7(18):eabd4676. doi: 10.1126/sciadv.abd4676. Print 2021 Apr. Sci Adv. 2021. PMID: 33931443 Free PMC article.
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.
Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP. Xu L, et al. Among authors: chen j, chen y. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095. doi: 10.1073/pnas.1712363115. Epub 2018 May 15. Proc Natl Acad Sci U S A. 2018. PMID: 29764999 Free PMC article.
MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.
Ke XY, Chen Y, Tham VY, Lin RY, Dakle P, Nacro K, Puhaindran ME, Houghton P, Pang A, Lee VK, Ding LW, Gery S, Hill J, Chen L, Xu L, Koeffler HP. Ke XY, et al. Among authors: chen l, chen y. Oncogene. 2021 Mar;40(10):1851-1867. doi: 10.1038/s41388-021-01661-4. Epub 2021 Feb 9. Oncogene. 2021. PMID: 33564073 Free PMC article.
Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.
Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Lin DC, et al. Among authors: chen y. Cancer Res. 2015 May 1;75(9):1815-27. doi: 10.1158/0008-5472.CAN-14-1433. Epub 2015 Apr 15. Cancer Res. 2015. PMID: 25877876 Free PMC article.
SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells.
Sun QY, Ding LW, Johnson K, Zhou S, Tyner JW, Yang H, Doan NB, Said JW, Xiao JF, Loh XY, Ran XB, Venkatachalam N, Lao Z, Chen Y, Xu L, Fan LF, Chien W, Lin DC, Koeffler HP. Sun QY, et al. Among authors: chen y. Oncogene. 2019 Aug;38(34):6196-6210. doi: 10.1038/s41388-019-0865-8. Epub 2019 Jul 22. Oncogene. 2019. PMID: 31332289
Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma.
Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP. Jiang YY, et al. Among authors: chen y. Gut. 2017 Aug;66(8):1358-1368. doi: 10.1136/gutjnl-2016-311818. Epub 2016 May 10. Gut. 2017. PMID: 27196599 Free PMC article.
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