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Intravenous functional gene transfer throughout the brain of non-human primates using AAV.
Chuapoco MR, Flytzanis NC, Goeden N, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shaya TF, Vendemiatti J, Jang MJ, Mich J, Bishaw Y, Gore B, Omstead V, Taskin N, Weed N, Ting J, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V. Chuapoco MR, et al. Among authors: chen x. Res Sq [Preprint]. 2023 Jan 13:rs.3.rs-1370972. doi: 10.21203/rs.3.rs-1370972/v1. Res Sq. 2023. PMID: 36789432 Free PMC article. Updated. Preprint.
Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.
Challis RC, Ravindra Kumar S, Chen X, Goertsen D, Coughlin GM, Hori AM, Chuapoco MR, Otis TS, Miles TF, Gradinaru V. Challis RC, et al. Among authors: chen x. Annu Rev Neurosci. 2022 Jul 8;45:447-469. doi: 10.1146/annurev-neuro-111020-100834. Epub 2022 Apr 19. Annu Rev Neurosci. 2022. PMID: 35440143 Free article. Review.
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.
Chen X, Ravindra Kumar S, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, Fox AS, Chiu IM, Gradinaru V. Chen X, et al. Neuron. 2022 Jul 20;110(14):2242-2257.e6. doi: 10.1016/j.neuron.2022.05.003. Epub 2022 May 27. Neuron. 2022. PMID: 35643078 Free PMC article.
Spatial transcriptomics for profiling the tropism of viral vectors in tissues.
Jang MJ, Coughlin GM, Jackson CR, Chen X, Chuapoco MR, Vendemiatti JL, Wang AZ, Gradinaru V. Jang MJ, et al. Among authors: chen x. Nat Biotechnol. 2023 Sep;41(9):1272-1286. doi: 10.1038/s41587-022-01648-w. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702899 Free PMC article.
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Kumar SR, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore B, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Chen X, et al. bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523844. doi: 10.1101/2023.01.12.523844. bioRxiv. 2023. PMID: 36711773 Free PMC article. Updated. Preprint.
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Chen X, et al. Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7. Nat Commun. 2023. PMID: 37291094 Free PMC article.
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