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Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, Kislinger T, Yip CM, Backx PH, Gourdie RG, Hamilton RM, Gramolini AO. Teng ACT, et al. Among authors: chen w. Nat Commun. 2022 Oct 18;13(1):6166. doi: 10.1038/s41467-022-33303-y. Nat Commun. 2022. PMID: 36257954 Free PMC article.
Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.
Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Massé S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH. Wauchop M, et al. Among authors: chen w. Biomaterials. 2023 Oct;301:122255. doi: 10.1016/j.biomaterials.2023.122255. Epub 2023 Jul 26. Biomaterials. 2023. PMID: 37651922
Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.
Lakin R, Polidovitch N, Yang S, Parikh M, Liu X, Debi R, Gao X, Chen W, Guzman C, Yakobov S, Izaddoustdar F, Wauchop M, Lei Q, Xu W, Nedospasov SA, Christoffels VM, Backx PH. Lakin R, et al. Among authors: chen w. Cardiovasc Res. 2023 Dec 19;119(16):2607-2622. doi: 10.1093/cvr/cvad144. Cardiovasc Res. 2023. PMID: 37713664
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