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Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism.
Szczepaniak P, Siedlinski M, Hodorowicz-Zaniewska D, Nosalski R, Mikolajczyk TP, Dobosz AM, Dikalova A, Dikalov S, Streb J, Gara K, Basta P, Krolczyk J, Sulicka-Grodzicka J, Jozefczuk E, Dziewulska A, Saju B, Laksa I, Chen W, Dormer J, Tomaszewski M, Maffia P, Czesnikiewicz-Guzik M, Crea F, Dobrzyn A, Moslehi J, Grodzicki T, Harrison DG, Guzik TJ. Szczepaniak P, et al. Among authors: chen w. J Clin Invest. 2022 Jul 1;132(13):e149117. doi: 10.1172/JCI149117. J Clin Invest. 2022. PMID: 35617030 Free PMC article.
Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.
Itani HA, McMaster WG Jr, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ. Itani HA, et al. Among authors: chen w. Hypertension. 2016 Jul;68(1):123-32. doi: 10.1161/HYPERTENSIONAHA.116.07237. Epub 2016 May 23. Hypertension. 2016. PMID: 27217403 Free PMC article.
DC isoketal-modified proteins activate T cells and promote hypertension.
Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG. Kirabo A, et al. Among authors: chen sc, chen w. J Clin Invest. 2014 Oct;124(10):4642-56. doi: 10.1172/JCI74084. Epub 2014 Sep 17. J Clin Invest. 2014. PMID: 25244096 Free PMC article.
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Wu J, et al. Among authors: chen w. J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. J Clin Invest. 2016. PMID: 26595812 Free PMC article.
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus.
Patrick DM, de la Visitación N, Krishnan J, Chen W, Ormseth MJ, Stein CM, Davies SS, Amarnath V, Crofford LJ, Williams JM, Zhao S, Smart CD, Dikalov S, Dikalova A, Xiao L, Van Beusecum JP, Ao M, Fogo AB, Kirabo A, Harrison DG. Patrick DM, et al. Among authors: chen w. JCI Insight. 2022 Jul 8;7(13):e136678. doi: 10.1172/jci.insight.136678. JCI Insight. 2022. PMID: 35608913 Free PMC article.
Phage-display-guided nanocarrier targeting to atheroprone vasculature.
Hofmeister LH, Lee SH, Norlander AE, Montaniel KR, Chen W, Harrison DG, Sung HJ. Hofmeister LH, et al. Among authors: chen w. ACS Nano. 2015;9(4):4435-46. doi: 10.1021/acsnano.5b01048. Epub 2015 Mar 23. ACS Nano. 2015. PMID: 25768046 Free PMC article.
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS. Saleh MA, et al. Among authors: chen w. J Clin Invest. 2015 Mar 2;125(3):1189-202. doi: 10.1172/JCI76327. Epub 2015 Feb 9. J Clin Invest. 2015. PMID: 25664851 Free PMC article.
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