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Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.
Wang MY, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RH, Roth MG. Wang MY, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6611-6616. doi: 10.1073/pnas.1705845114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584109 Free PMC article.
Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.
Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL. Sharma AX, et al. Among authors: chen s. Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065. Cell Rep. 2018. PMID: 29444429 Free PMC article.
Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. Ye R, et al. Among authors: chen z, chen s. J Clin Invest. 2018 Mar 1;128(3):1178-1189. doi: 10.1172/JCI97702. Epub 2018 Feb 19. J Clin Invest. 2018. PMID: 29457786 Free PMC article.
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.
Wang MY, Dean ED, Quittner-Strom E, Zhu Y, Chowdhury KH, Zhang Z, Zhao S, Li N, Ye R, Lee Y, Zhang Y, Chen S, Yu X, Leonard DC, Poffenberger G, Von Deylen A, McCorkle SK, Schlegel A, Sloop KW, Efanov AM, Gimeno RE, Scherer PE, Powers AC, Unger RH, Holland WL. Wang MY, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2022142118. doi: 10.1073/pnas.2022142118. Proc Natl Acad Sci U S A. 2021. PMID: 33619103 Free PMC article.
Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
Cannavino J, Shao M, An YA, Bezprozvannaya S, Chen S, Kim J, Xu L, McAnally JR, Scherer PE, Liu N, Gupta RK, Bassel-Duby R, Olson EN. Cannavino J, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2104650118. doi: 10.1073/pnas.2104650118. Proc Natl Acad Sci U S A. 2021. PMID: 34088848 Free PMC article.
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