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Metabolism, pharmacokinetics, and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin A3-induced hepatotoxicity.
Xie Y, Zhou X, Pei H, Chen MC, Sun ZL, Xue YR, Tian XT, Huang CG. Xie Y, et al. Among authors: chen mc. Acta Pharmacol Sin. 2018 Dec;39(12):1923-1934. doi: 10.1038/s41401-018-0012-z. Epub 2018 May 23. Acta Pharmacol Sin. 2018. PMID: 29795136 Free PMC article.
Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro.
Tian X, Liu H, Qiao S, Yin H, Chen M, Hu P, Wang Y, Peng H, Liu F, Pan G, Huang C. Tian X, et al. J Ethnopharmacol. 2019 May 23;236:161-172. doi: 10.1016/j.jep.2019.02.022. Epub 2019 Feb 22. J Ethnopharmacol. 2019. PMID: 30802610
Correction to: Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests.
Zhong M, Tian X, Chen S, Chen M, Guo Z, Zhang M, Zheng G, Li Z, Shi Z, Wang G, Gao H, Liu F, Huang C. Zhong M, et al. Chin Med. 2020 Apr 2;15:32. doi: 10.1186/s13020-020-00312-2. eCollection 2020. Chin Med. 2020. PMID: 32266001 Free PMC article.
Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats.
Tian X, Xu Z, Chen M, Hu P, Liu F, Sun Z, Liu H, Guo X, Li Z, Huang C. Tian X, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:122-131. doi: 10.1016/j.jchromb.2018.03.013. Epub 2018 Mar 9. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29597038
1,456 results