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BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis.
Tiwari S, Dutt TS, Chen B, Chen M, Kim J, Dai AZ, Lukose R, Shanley C, Fox A, Karger BR, Porcelli SA, Chan J, Podell BK, Obregon-Henao A, Orme IM, Jacobs WR Jr, Henao-Tamayo M. Tiwari S, et al. Among authors: chen m, chen b. Vaccine. 2020 Oct 21;38(45):7156-7165. doi: 10.1016/j.vaccine.2020.08.004. Epub 2020 Sep 23. Vaccine. 2020. PMID: 32978002 Free PMC article.
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR Jr. Hsu T, et al. Among authors: chen m, chen b. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13. Proc Natl Acad Sci U S A. 2003. PMID: 14557547 Free PMC article.
Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.
Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR Jr. Sambandamurthy VK, et al. Among authors: chen m, chen b. Vaccine. 2006 Sep 11;24(37-39):6309-20. doi: 10.1016/j.vaccine.2006.05.097. Epub 2006 Jun 12. Vaccine. 2006. PMID: 16860907
Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
Derrick SC, Evering TH, Sambandamurthy VK, Jalapathy KV, Hsu T, Chen B, Chen M, Russell RG, Junqueira-Kipnis AP, Orme IM, Porcelli SA, Jacobs WR Jr, Morris SL. Derrick SC, et al. Among authors: chen m, chen b. Immunology. 2007 Feb;120(2):192-206. doi: 10.1111/j.1365-2567.2006.02491.x. Epub 2006 Oct 31. Immunology. 2007. PMID: 17076705 Free PMC article.
Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis.
Junqueira-Kipnis AP, de Oliveira FM, Trentini MM, Tiwari S, Chen B, Resende DP, Silva BD, Chen M, Tesfa L, Jacobs WR Jr, Kipnis A. Junqueira-Kipnis AP, et al. Among authors: chen m, chen b. PLoS One. 2013 Nov 8;8(11):e78639. doi: 10.1371/journal.pone.0078639. eCollection 2013. PLoS One. 2013. PMID: 24250805 Free PMC article.
Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis.
Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR Jr. Tiwari S, et al. Among authors: chen m, chen b. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9779-9784. doi: 10.1073/pnas.1808874115. Epub 2018 Aug 24. Proc Natl Acad Sci U S A. 2018. PMID: 30143580 Free PMC article.
A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.
Bhatt K, Machado H, Osório NS, Sousa J, Cardoso F, Magalhães C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR Jr, Bhatt A, Saraiva M. Bhatt K, et al. Among authors: chen m, chen b. mSphere. 2018 Oct 31;3(5):e00352-18. doi: 10.1128/mSphere.00352-18. mSphere. 2018. PMID: 30381350 Free PMC article.
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