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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H. Shao Z, et al. Among authors: chen zh, chen ln. Nat Chem Biol. 2022 Mar;18(3):264-271. doi: 10.1038/s41589-021-00918-z. Epub 2021 Dec 23. Nat Chem Biol. 2022. PMID: 34949837 Free PMC article.
Cryo-EM structures of inactive and active GABAB receptor.
Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y. Mao C, et al. Among authors: chen ln. Cell Res. 2020 Jul;30(7):564-573. doi: 10.1038/s41422-020-0350-5. Epub 2020 Jun 3. Cell Res. 2020. PMID: 32494023 Free PMC article.
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: chen ln, chen y. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: chen ln, chen y. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.
243 results